Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4916610..4917126 Replicon chromosome
Accession NZ_CP096234
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02357

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M0537_RS23685 Protein ID WP_004178374.1
Coordinates 4916610..4916894 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M0537_RS23690 Protein ID WP_002886901.1
Coordinates 4916884..4917126 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0537_RS23660 (4912006) 4912006..4912269 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
M0537_RS23665 (4912399) 4912399..4912572 + 174 WP_041169004.1 hypothetical protein -
M0537_RS23670 (4912575) 4912575..4913318 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M0537_RS23675 (4913675) 4913675..4915813 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M0537_RS23680 (4916142) 4916142..4916606 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M0537_RS23685 (4916610) 4916610..4916894 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M0537_RS23690 (4916884) 4916884..4917126 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M0537_RS23695 (4917204) 4917204..4919114 - 1911 WP_012737231.1 PRD domain-containing protein -
M0537_RS23700 (4919137) 4919137..4920291 - 1155 WP_012737230.1 lactonase family protein -
M0537_RS23705 (4920358) 4920358..4921098 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T242929 WP_004178374.1 NZ_CP096234:c4916894-4916610 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T242929 NZ_OW968111:1835807-1836061 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT242929 WP_002886901.1 NZ_CP096234:c4917126-4916884 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT242929 NZ_OW968111:1835559-1835810 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References