Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 100179..101089 Replicon plasmid pVirH39
Accession NZ_CP096231
Organism Klebsiella pneumoniae subsp. pneumoniae strain H39

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag M0538_RS26810 Protein ID WP_004026354.1
Coordinates 100179..100649 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag M0538_RS26815 Protein ID WP_004026357.1
Coordinates 100646..101089 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0538_RS26770 (M0538_26735) 95263..95865 - 603 WP_011251277.1 HAD domain-containing protein -
M0538_RS26775 (M0538_26740) 95868..96383 - 516 WP_041937820.1 hypothetical protein -
M0538_RS26780 (M0538_26745) 96491..97003 - 513 WP_048333449.1 hypothetical protein -
M0538_RS26785 (M0538_26750) 97183..98139 - 957 WP_011251280.1 DsbA family protein -
M0538_RS26790 (M0538_26755) 98199..98540 - 342 WP_011251281.1 hypothetical protein -
M0538_RS26795 (M0538_26760) 98554..98865 - 312 WP_011251282.1 hypothetical protein -
M0538_RS26800 (M0538_26765) 98882..99331 - 450 WP_011251283.1 thioredoxin fold domain-containing protein -
M0538_RS26810 (M0538_26775) 100179..100649 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
M0538_RS26815 (M0538_26780) 100646..101089 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
M0538_RS26820 (M0538_26785) 101190..101693 - 504 Protein_109 DUF4113 domain-containing protein -
M0538_RS26825 (M0538_26790) 101791..102012 - 222 WP_004213643.1 DUF2188 domain-containing protein -
M0538_RS26830 (M0538_26795) 102187..102312 - 126 Protein_111 Fe3+-citrate ABC transporter substrate-binding protein -
M0538_RS26835 (M0538_26800) 102387..104513 - 2127 WP_004213640.1 TonB-dependent Fe(3+) dicitrate receptor FecA -
M0538_RS26840 (M0538_26805) 104600..105553 - 954 Protein_113 fec operon regulator FecR -
M0538_RS26845 (M0538_26810) 105550..106071 - 522 WP_004213635.1 ferric citrate uptake sigma factor FecI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA / pla 1..229037 229037
- flank IS/Tn - - 99333..99836 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T242911 WP_004026354.1 NZ_CP096231:c100649-100179 [Klebsiella pneumoniae subsp. pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T242911 NZ_OW968011:2341757-2342221 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT242911 WP_004026357.1 NZ_CP096231:c101089-100646 [Klebsiella pneumoniae subsp. pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT242911 NZ_OW968011:2341422-2341757 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References