Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 796414..797071 Replicon chromosome
Accession NZ_CP096230
Organism Klebsiella pneumoniae subsp. pneumoniae strain H39

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag M0538_RS03955 Protein ID WP_002916310.1
Coordinates 796661..797071 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M0538_RS03950 Protein ID WP_002916312.1
Coordinates 796414..796680 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0538_RS03925 (791622) 791622..793055 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
M0538_RS03930 (793174) 793174..793902 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
M0538_RS03935 (793952) 793952..794263 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
M0538_RS03940 (794427) 794427..795086 + 660 WP_002916317.1 hemolysin III family protein -
M0538_RS03945 (795185) 795185..796168 - 984 WP_014906951.1 tRNA-modifying protein YgfZ -
M0538_RS03950 (796414) 796414..796680 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M0538_RS03955 (796661) 796661..797071 + 411 WP_002916310.1 protein YgfX Toxin
M0538_RS03960 (797078) 797078..797599 - 522 WP_002916308.1 flavodoxin FldB -
M0538_RS03965 (797700) 797700..798596 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M0538_RS03970 (798619) 798619..799332 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M0538_RS03975 (799338) 799338..801071 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T242896 WP_002916310.1 NZ_CP096230:796661-797071 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T242896 NZ_OW967977:56134-56286 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT242896 WP_002916312.1 NZ_CP096230:796414-796680 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT242896 NZ_OW967977:c56084-56022 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References