Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5066881..5067548 Replicon chromosome
Accession NZ_CP096227
Organism Xanthomonas citri pv. citri strain CQ13

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag XCQ_RS21700 Protein ID WP_005916679.1
Coordinates 5067132..5067548 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag XCQ_RS21695 Protein ID WP_005916676.1
Coordinates 5066881..5067135 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XCQ_RS21670 (XCQ_21670) 5063043..5063222 + 180 WP_011052886.1 RNA 2'-phosphotransferase -
XCQ_RS21675 (XCQ_21675) 5063379..5064644 + 1266 WP_015463799.1 phospholipase D-like domain-containing protein -
XCQ_RS21680 (XCQ_21680) 5064670..5065197 - 528 WP_005916668.1 hypothetical protein -
XCQ_RS21685 (XCQ_21685) 5065436..5065642 + 207 WP_003489327.1 hypothetical protein -
XCQ_RS21690 (XCQ_21690) 5065629..5066735 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
XCQ_RS21695 (XCQ_21695) 5066881..5067135 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
XCQ_RS21700 (XCQ_21700) 5067132..5067548 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
XCQ_RS21705 (XCQ_21705) 5067670..5067873 - 204 WP_131830033.1 hypothetical protein -
XCQ_RS21710 (XCQ_21710) 5068001..5068213 - 213 WP_015472901.1 hypothetical protein -
XCQ_RS21715 (XCQ_21715) 5068470..5070089 + 1620 WP_015463800.1 alpha/beta hydrolase-fold protein -
XCQ_RS21720 (XCQ_21720) 5070193..5070591 - 399 WP_004429277.1 DUF2384 domain-containing protein -
XCQ_RS21725 (XCQ_21725) 5070907..5071338 + 432 WP_005922907.1 hypothetical protein -
XCQ_RS21730 (XCQ_21730) 5071367..5071597 - 231 WP_223293191.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T242890 WP_005916679.1 NZ_CP096227:5067132-5067548 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T242890 NZ_OW967975:3759682-3759960 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT242890 WP_005916676.1 NZ_CP096227:5066881-5067135 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT242890 NZ_OW967975:3759419-3759679 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References