Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 214629..215158 Replicon chromosome
Accession NZ_CP096219
Organism Enterococcus faecium strain UCH5

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag M0F39_RS01055 Protein ID WP_002296560.1
Coordinates 214892..215158 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag M0F39_RS01050 Protein ID WP_002296559.1
Coordinates 214629..214892 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0F39_RS01040 (M0F39_01040) 212003..213826 + 1824 WP_002294202.1 APC family permease -
M0F39_RS01045 (M0F39_01045) 213968..214153 - 186 WP_002296558.1 transcriptional regulator -
M0F39_RS01050 (M0F39_01050) 214629..214892 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M0F39_RS01055 (M0F39_01055) 214892..215158 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
M0F39_RS01060 (M0F39_01060) 215359..215847 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
M0F39_RS01065 (M0F39_01065) 216388..217059 - 672 WP_002302663.1 ABC transporter permease -
M0F39_RS01070 (M0F39_01070) 217056..217973 - 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
M0F39_RS01075 (M0F39_01075) 217970..218611 - 642 WP_002293405.1 ABC transporter permease -
M0F39_RS01080 (M0F39_01080) 218615..219196 - 582 Protein_215 CBS domain-containing protein -
M0F39_RS01085 (M0F39_01085) 219354..219758 + 405 WP_002287522.1 IS200/IS605-like element ISEfa4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T242882 WP_002296560.1 NZ_CP096219:214892-215158 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T242882 NZ_OW967975:2008440-2008543 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT242882 WP_002296559.1 NZ_CP096219:214629-214892 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT242882 NZ_OW967975:c2008581-2008310 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References