Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 216831..217360 Replicon chromosome
Accession NZ_CP096211
Organism Enterococcus faecium strain UCH1

Toxin (Protein)


Gene name relE Uniprot ID A0A828ZPW6
Locus tag M0E25_RS01065 Protein ID WP_002301121.1
Coordinates 217094..217360 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag M0E25_RS01060 Protein ID WP_002294199.1
Coordinates 216831..217094 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0E25_RS01050 (M0E25_01050) 214206..216029 + 1824 WP_002294202.1 APC family permease -
M0E25_RS01055 (M0E25_01055) 216171..216356 - 186 WP_002348885.1 hypothetical protein -
M0E25_RS16375 216363..216491 + 129 WP_002294200.1 hypothetical protein -
M0E25_RS01060 (M0E25_01060) 216831..217094 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M0E25_RS01065 (M0E25_01065) 217094..217360 + 267 WP_002301121.1 Txe/YoeB family addiction module toxin Toxin
M0E25_RS01070 (M0E25_01070) 217561..218049 + 489 WP_002301120.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
M0E25_RS01075 (M0E25_01075) 218591..219262 - 672 WP_002301116.1 ABC transporter permease -
M0E25_RS01080 (M0E25_01080) 219259..220176 - 918 WP_002301114.1 osmoprotectant ABC transporter substrate-binding protein -
M0E25_RS01085 (M0E25_01085) 220173..220814 - 642 WP_002293405.1 ABC transporter permease -
M0E25_RS01090 (M0E25_01090) 220818..221993 - 1176 WP_002348889.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10619.04 Da        Isoelectric Point: 9.8346

>T242876 WP_002301121.1 NZ_CP096211:217094-217360 [Enterococcus faecium]
MSNYTVAIKNSATVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T242876 NZ_OW967975:649983-650297 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT242876 WP_002294199.1 NZ_CP096211:216831-217094 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT242876 NZ_OW967975:650294-650710 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZPW6

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References