Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5371375..5371880 Replicon chromosome
Accession NZ_CP096207
Organism Pseudomonas aeruginosa TBCF10839

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag M0D10_RS25185 Protein ID WP_003083773.1
Coordinates 5371599..5371880 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag M0D10_RS25180 Protein ID WP_003112628.1
Coordinates 5371375..5371602 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0D10_RS25155 (M0D10_25100) 5366393..5367886 + 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
M0D10_RS25160 (M0D10_25105) 5368055..5369482 + 1428 WP_003083784.1 GABA permease -
M0D10_RS25165 (M0D10_25110) 5369564..5369905 - 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
M0D10_RS25170 (M0D10_25115) 5369978..5370478 - 501 WP_003101228.1 LEA type 2 family protein -
M0D10_RS25175 (M0D10_25120) 5370579..5371199 + 621 WP_003101226.1 hypothetical protein -
M0D10_RS25180 (M0D10_25125) 5371375..5371602 + 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
M0D10_RS25185 (M0D10_25130) 5371599..5371880 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
M0D10_RS25190 (M0D10_25135) 5372180..5373088 + 909 WP_003083769.1 LysR family transcriptional regulator -
M0D10_RS25195 (M0D10_25140) 5373120..5373530 - 411 WP_003101225.1 aegerolysin family protein -
M0D10_RS25200 (M0D10_25145) 5373710..5374444 - 735 WP_003117208.1 GntR family transcriptional regulator -
M0D10_RS25205 (M0D10_25150) 5374545..5375231 - 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
M0D10_RS25210 (M0D10_25155) 5375280..5376629 - 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T242874 WP_003083773.1 NZ_CP096207:5371599-5371880 [Pseudomonas aeruginosa TBCF10839]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T242874 NZ_OW967975:182729-182836 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT242874 WP_003112628.1 NZ_CP096207:5371375-5371602 [Pseudomonas aeruginosa TBCF10839]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT242874 NZ_OW967975:c182681-182615 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References