Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4064597..4065308 Replicon chromosome
Accession NZ_CP096207
Organism Pseudomonas aeruginosa TBCF10839

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag M0D10_RS18985 Protein ID WP_033971890.1
Coordinates 4064597..4064779 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M0D10_RS18990 Protein ID WP_058168140.1
Coordinates 4064826..4065308 (+) Length 161 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0D10_RS18955 (M0D10_18905) 4061347..4061874 - 528 WP_023117090.1 terminase small subunit -
M0D10_RS18960 (M0D10_18910) 4062005..4062748 - 744 WP_128542530.1 hypothetical protein -
M0D10_RS18965 (M0D10_18915) 4062745..4063215 - 471 WP_124173773.1 lysis system i-spanin subunit Rz -
M0D10_RS18970 (M0D10_18920) 4063212..4063451 - 240 WP_023114598.1 hypothetical protein -
M0D10_RS18975 (M0D10_18925) 4063451..4064068 - 618 WP_128542531.1 glycoside hydrolase family 19 protein -
M0D10_RS18980 (M0D10_18930) 4064065..4064397 - 333 WP_043494869.1 phage holin, lambda family -
M0D10_RS18985 (M0D10_18935) 4064597..4064779 + 183 WP_033971890.1 type II toxin-antitoxin system HicA family toxin Toxin
M0D10_RS18990 (M0D10_18940) 4064826..4065308 + 483 WP_058168140.1 transcriptional regulator Antitoxin
M0D10_RS18995 (M0D10_18945) 4065419..4066093 - 675 WP_021205614.1 hypothetical protein -
M0D10_RS19000 (M0D10_18950) 4066131..4066430 - 300 WP_128542532.1 hypothetical protein -
M0D10_RS19005 (M0D10_18955) 4066427..4066774 - 348 WP_033950489.1 RusA family crossover junction endodeoxyribonuclease -
M0D10_RS19010 (M0D10_18960) 4066771..4067142 - 372 WP_031630618.1 Ref family recombination enhancement nuclease -
M0D10_RS19015 (M0D10_18965) 4067139..4067345 - 207 WP_003159465.1 hypothetical protein -
M0D10_RS19020 (M0D10_18970) 4067342..4068025 - 684 WP_128542533.1 replication protein P -
M0D10_RS19025 (M0D10_18975) 4068022..4068777 - 756 WP_128542534.1 helix-turn-helix domain-containing protein -
M0D10_RS19030 (M0D10_18980) 4068842..4069555 - 714 WP_033955042.1 phage antirepressor KilAC domain-containing protein -
M0D10_RS19035 (M0D10_18985) 4069675..4069881 - 207 WP_058161116.1 Cro/CI family transcriptional regulator -
M0D10_RS19040 (M0D10_18990) 4069990..4070115 + 126 Protein_3764 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4041229..4091019 49790


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-78)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6776.89 Da        Isoelectric Point: 11.0775

>T242873 WP_033971890.1 NZ_CP096207:4064597-4064779 [Pseudomonas aeruginosa TBCF10839]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGTKEMPEPTRKAIIKQLGLK

Download         Length: 183 bp

>T242873 NZ_OW967967:105754-106134 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTAGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin


Download         Length: 161 a.a.        Molecular weight: 18149.69 Da        Isoelectric Point: 5.0964

>AT242873 WP_058168140.1 NZ_CP096207:4064826-4065308 [Pseudomonas aeruginosa TBCF10839]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKAHAISEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KIALWNEMVRRDMRKADLCRLLGIAQTQGDRLVDFLHNTKMEALENALDFLGLRLRVQIERDKDVERKMAEPPERGKLRA

Download         Length: 483 bp

>AT242873 NZ_OW967967:105533-105754 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References