Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 3009415..3010457 | Replicon | chromosome |
| Accession | NZ_CP096207 | ||
| Organism | Pseudomonas aeruginosa TBCF10839 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | M0D10_RS13890 | Protein ID | WP_003153636.1 |
| Coordinates | 3009415..3009990 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | M0D10_RS13895 | Protein ID | WP_003050245.1 |
| Coordinates | 3009987..3010457 (-) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M0D10_RS13865 (M0D10_13830) | 3005853..3006578 | - | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
| M0D10_RS13870 (M0D10_13835) | 3006617..3007519 | - | 903 | WP_003090158.1 | CBASS oligonucleotide cyclase | - |
| M0D10_RS13875 (M0D10_13840) | 3007519..3008019 | - | 501 | WP_003090159.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap7 | - |
| M0D10_RS13880 (M0D10_13845) | 3008016..3008486 | - | 471 | WP_003090160.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap8 | - |
| M0D10_RS13885 (M0D10_13850) | 3008483..3009397 | - | 915 | WP_016852809.1 | AAA family ATPase | - |
| M0D10_RS13890 (M0D10_13855) | 3009415..3009990 | - | 576 | WP_003153636.1 | PIN domain-containing protein | Toxin |
| M0D10_RS13895 (M0D10_13860) | 3009987..3010457 | - | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| M0D10_RS13900 (M0D10_13865) | 3010661..3011044 | + | 384 | WP_003090167.1 | RAQPRD family integrative conjugative element protein | - |
| M0D10_RS13905 (M0D10_13870) | 3011041..3011274 | + | 234 | WP_003090170.1 | TIGR03758 family integrating conjugative element protein | - |
| M0D10_RS13910 (M0D10_13875) | 3011291..3011650 | + | 360 | WP_003090173.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| M0D10_RS13915 (M0D10_13880) | 3011662..3012060 | + | 399 | WP_003105639.1 | TIGR03750 family conjugal transfer protein | - |
| M0D10_RS13920 (M0D10_13885) | 3012057..3012749 | + | 693 | WP_023100424.1 | TIGR03746 family integrating conjugative element protein | - |
| M0D10_RS13925 (M0D10_13890) | 3012746..3013657 | + | 912 | WP_023100423.1 | TIGR03749 family integrating conjugative element protein | - |
| M0D10_RS13930 (M0D10_13895) | 3013647..3015065 | + | 1419 | WP_023100422.1 | TIGR03752 family integrating conjugative element protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2963300..3096333 | 133033 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21629.78 Da Isoelectric Point: 5.9995
>T242870 WP_003153636.1 NZ_CP096207:c3009990-3009415 [Pseudomonas aeruginosa TBCF10839]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T242870 NZ_OW967966:c4880817-4880506 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT242870 WP_003050245.1 NZ_CP096207:c3010457-3009987 [Pseudomonas aeruginosa TBCF10839]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT242870 NZ_OW967966:c4880505-4880215 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|