Detailed information of TA system TA242869

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1666429..1667650
• Replicon: chromosome
• Accession: NZ_CP096207
• Organism: Pseudomonas aeruginosa TBCF10839

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: M0D10_RS07880
• Protein ID: WP_128542562.1
• Coordinates: 1666429..1667007 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: M0D10_RS07885
• Protein ID: WP_003088112.1
• Coordinates: 1667096..1667650 (-)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0D10_RS07865 (M0D10_07850)	1661706..1662983	+	1278	WP_003102743.1	TolC family protein	-
M0D10_RS07870 (M0D10_07855)	1662973..1665144	+	2172	WP_042853313.1	type I secretion system permease/ATPase	-
M0D10_RS07875 (M0D10_07860)	1665134..1666321	+	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
M0D10_RS07880 (M0D10_07865)	1666429..1667007	-	579	WP_128542562.1	HD domain-containing protein	Toxin
M0D10_RS07885 (M0D10_07870)	1667096..1667650	-	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
M0D10_RS07890 (M0D10_07875)	1667808..1670003	-	2196	WP_003122807.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
M0D10_RS07895 (M0D10_07880)	1670008..1670469	-	462	WP_034038312.1	(2Fe-2S)-binding protein	-
M0D10_RS07900 (M0D10_07885)	1670800..1671123	+	324	WP_034038313.1	multidrug efflux SMR transporter	-
M0D10_RS07905 (M0D10_07890)	1671136..1671534	+	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
M0D10_RS07910 (M0D10_07895)	1671531..1672082	-	552	WP_003102727.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21931.77 Da
• Isoelectric Point: 5.3655

>T242869 WP_128542562.1 NZ_CP096207:c1667007-1666429 [Pseudomonas aeruginosa TBCF10839]
MSLELLSNRLEFFREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Nucleotide

• Length: 579 bp

>T242869 NZ_OW967966:c4663203-4662817 [Escherichia coli]
GTGCTTGCCCCAACTGGGCCATGCAATCATCTTCATGTGATTTGTAATGATCCTGTTTATTACCCCGTTAACGATTGTTA
TTGTGTTTTAGTTGTTAATATTTCTAGTATCAAGGATGGTGTCCCCCACGATCCGTCTTGCGTCTTGAATTCTGGTGATC
ATCGCTTTATCAAGCATCCAAGTTATGTTGTTTACGCTGAAGCTATAATTTGGCGAGTGGATAACATGGTTAGAAAGCAG
CGATCGGGTGAGATTTCTGTTCATGATGATATGCCAGAAGCTACATTCAATAGAATTCTGGACGGTTTTGATATATCTGA
TGAAGTTACGCCAAAGAACCTTAAATTTAAAAATAAATATTGCGTATCATCTATTGATGATGAGTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT242869 WP_003088112.1 NZ_CP096207:c1667650-1667096 [Pseudomonas aeruginosa TBCF10839]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT242869 NZ_OW967966:c4663742-4663233 [Escherichia coli]
ATGGCATATCTGAAATTGATGAAGCTGCTCTATCTGTCTAACCGCAAGTCGATTTTGAAGCATGGCAGGATGATCGGCGA
AGATAGTCTTTACTCTATGAAATTTGGTCCAGTCATGTCGAATACGCTGAACTTGATTCGTGGTAAGGCTGAAGGCATTG
GTGACTACTGGTACAACTTGATAGAGACGAACGGGCATGATGTGTTGTTGCGTTCAGATCCGAGGGAAATGGATGCAGAC
GAGGTCTTTGATGAGTTGAGCCGTGCAGATATCCGGATTTTAGATGAAATCTATTCTCTGTATGGGCATATGAACCGATT
TGATCTCGCAAACATGACGCATTTAGAAAGCGTTTGTCCAGAGTGGCATAATCCTGGCAATTCTCGTAAGCCTATAGACC
TGAAAGAAATGCTGATCAGTGAGGGTAAAAGCGAGGATGAGGCTAATCGTATAATTGGCAAAATGGAAGAATCTCAGAAA
CTTAAGGAATTTTCTTTGCAATTATCATGA