Detailed information of TA system TA242868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 743382..744639
• Replicon: chromosome
• Accession: NZ_CP096207
• Organism: Pseudomonas aeruginosa TBCF10839

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: M0D10_RS03550
• Protein ID: WP_003449003.1
• Coordinates: 743884..744639 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: M0D10_RS03545
• Protein ID: WP_003086329.1
• Coordinates: 743382..743750 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0D10_RS03525 (M0D10_03520)	739545..739820	+	276	WP_169057979.1	zinc ribbon domain-containing protein	-
M0D10_RS03530 (M0D10_03525)	739823..740299	-	477	WP_003112531.1	hypothetical protein	-
M0D10_RS03535 (M0D10_03530)	740378..741967	+	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
M0D10_RS03540 (M0D10_03535)	742023..743309	+	1287	WP_003112529.1	FAD-binding oxidoreductase	-
M0D10_RS03545 (M0D10_03540)	743382..743750	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
M0D10_RS03550 (M0D10_03545)	743884..744639	+	756	WP_003449003.1	RES family NAD+ phosphorylase	Toxin
M0D10_RS03555 (M0D10_03550)	745407..746768	+	1362	WP_003081943.1	DNA recombination protein RmuC	-
M0D10_RS03560 (M0D10_03555)	746923..749466	-	2544	WP_033876574.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28292.45 Da
• Isoelectric Point: 7.7294

>T242868 WP_003449003.1 NZ_CP096207:743884-744639 [Pseudomonas aeruginosa TBCF10839]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T242868 NZ_OW967966:c4537827-4537654 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGCGCATTCCTGGTCGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT242868 WP_003086329.1 NZ_CP096207:743382-743750 [Pseudomonas aeruginosa TBCF10839]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT242868 NZ_OW967966:c4538151-4537855 [Escherichia coli]
ATGGAAGGTAAAAATAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: V6AJU7