Detailed information of TA system TA242867

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1482658..1483327
• Replicon: chromosome
• Accession: NZ_CP096206
• Organism: Ignavigranum ruoffiae strain CPL 242382-20

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: M0R79_RS06995
• Protein ID: WP_248415870.1
• Coordinates: 1482658..1482828 (+)
• Length: 57 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: M0R79_RS07000
• Protein ID: WP_248415869.1
• Coordinates: 1482893..1483327 (+)
• Length: 145 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0R79_RS06970 (M0R79_05405)	1478056..1478685	-	630	WP_248415875.1	TetR/AcrR family transcriptional regulator	-
M0R79_RS06975 (M0R79_05400)	1479012..1479317	-	306	WP_248415874.1	DUF503 family protein	-
M0R79_RS06980 (M0R79_05395)	1479372..1479983	-	612	WP_248415873.1	Type 1 glutamine amidotransferase-like domain-containing protein	-
M0R79_RS06985 (M0R79_05385)	1481019..1481435	+	417	WP_248415872.1	helix-turn-helix transcriptional regulator	-
M0R79_RS06990 (M0R79_05380)	1481432..1481956	+	525	WP_248415871.1	hypothetical protein	-
M0R79_RS06995 (M0R79_05375)	1482658..1482828	+	171	WP_248415870.1	type II toxin-antitoxin system HicA family toxin	Toxin
M0R79_RS07000 (M0R79_05370)	1482893..1483327	+	435	WP_248415869.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
M0R79_RS07005 (M0R79_05365)	1483500..1483691	+	192	WP_248415868.1	type II toxin-antitoxin system HicA family toxin	-
M0R79_RS07010 (M0R79_05360)	1483740..1484117	+	378	WP_248415867.1	type II toxin-antitoxin system HicB family antitoxin	-
M0R79_RS07015 (M0R79_05355)	1484357..1485283	-	927	WP_248415866.1	DUF4349 domain-containing protein	-
M0R79_RS07020 (M0R79_05350)	1485507..1486187	-	681	WP_248415865.1	metal-dependent hydrolase	-
M0R79_RS07025 (M0R79_05345)	1486216..1487004	-	789	WP_248415864.1	glutathione-dependent disulfide-bond oxidoreductase	-
M0R79_RS07030 (M0R79_05340)	1487274..1487606	-	333	WP_248415863.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1462153..1486187	24034

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-56)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-70)

Sequences

Toxin

Protein

• Length: 57 a.a.
• Molecular weight: 6379.66 Da
• Isoelectric Point: 11.3658

>T242867 WP_248415870.1 NZ_CP096206:1482658-1482828 [Ignavigranum ruoffiae]
MPMNQREMIKLLKKNGWTHTSNKGKGSHIIMKKPNHGSIIIPKSELKIGTERSILK

Nucleotide

• Length: 171 bp

>T242867 NZ_OW967966:c4436276-4435926 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 145 a.a.
• Molecular weight: 16096.07 Da
• Isoelectric Point: 3.9777

>AT242867 WP_248415869.1 NZ_CP096206:1482893-1483327 [Ignavigranum ruoffiae]
MKAVYPAIFYYDNNSNGYFITFPDFEQSATQGDTINEAMEMAAEYLGMAIADIIESNQELPTPSNINGLSLTANHTVMDD
DEFETFTDLSKSFISLVPTDVSQYLGMDKLVKKTLTIPKWADTIGKELRLNFSQTLTEAIAQKN

Nucleotide

• Length: 435 bp

>AT242867 NZ_OW967966:c4436521-4436270 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA