Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4981922..4982538 Replicon chromosome
Accession NZ_CP096201
Organism Kluyvera ascorbata strain SK

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MY052_RS23795 Protein ID WP_202216873.1
Coordinates 4981922..4982293 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MY052_RS23800 Protein ID WP_202216874.1
Coordinates 4982290..4982538 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY052_RS23780 (MY052_23780) 4979427..4980329 + 903 WP_035892321.1 formate dehydrogenase subunit beta -
MY052_RS23785 (MY052_23785) 4980326..4980961 + 636 WP_035892320.1 formate dehydrogenase cytochrome b556 subunit -
MY052_RS23790 (MY052_23790) 4980958..4981887 + 930 WP_035892319.1 formate dehydrogenase accessory protein FdhE -
MY052_RS23795 (MY052_23795) 4981922..4982293 - 372 WP_202216873.1 type II toxin-antitoxin system VapC family toxin Toxin
MY052_RS23800 (MY052_23800) 4982290..4982538 - 249 WP_202216874.1 CopG family transcriptional regulator Antitoxin
MY052_RS23805 (MY052_23805) 4982743..4983654 + 912 WP_248537970.1 alpha/beta hydrolase -
MY052_RS23810 (MY052_23810) 4983678..4984619 - 942 WP_185064490.1 fatty acid biosynthesis protein FabY -
MY052_RS23815 (MY052_23815) 4984664..4985101 - 438 WP_035892312.1 D-aminoacyl-tRNA deacylase -
MY052_RS23820 (MY052_23820) 4985098..4985964 - 867 WP_035892311.1 virulence factor BrkB family protein -
MY052_RS23825 (MY052_23825) 4985958..4986557 - 600 WP_248537971.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-109)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14019.39 Da        Isoelectric Point: 8.5624

>T242865 WP_202216873.1 NZ_CP096201:c4982293-4981922 [Kluyvera ascorbata]
MKRPVLFDTNILIDLFSGRMEAKRAMDSYPPQHAISLITWMEVMIGAKRFHQEQRTRIALSAFEIIGVTEEIAEQSVNLR
QEYGMKLPDAIILATAHVHRRELVTRNTKDFAGLPGVILPYAL

Download         Length: 372 bp

>T242865 NZ_OW967966:c4003731-4003333 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACAGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9745.14 Da        Isoelectric Point: 4.4777

>AT242865 WP_202216874.1 NZ_CP096201:c4982538-4982290 [Kluyvera ascorbata]
MMVERDMGRILLDLSDEVIKRLDILKQQRNLPRAELLREAVEQYLEKQSQAELTISGALGIWQGCEEDSVEYERKLREEW
PR

Download         Length: 249 bp

>AT242865 NZ_OW967966:c4004027-4003734 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAACTGGTTAAGGCGCGCTTCCGTCCGAGTGCCGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References