Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3240362..3241141 Replicon chromosome
Accession NZ_CP096201
Organism Kluyvera ascorbata strain SK

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag MY052_RS15540 Protein ID WP_248537373.1
Coordinates 3240764..3241141 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MY052_RS15535 Protein ID WP_248537372.1
Coordinates 3240362..3240715 (+) Length 118 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY052_RS15495 (MY052_15495) 3236283..3236435 + 153 WP_167809833.1 hypothetical protein -
MY052_RS15500 (MY052_15500) 3236571..3237005 + 435 WP_248537365.1 hypothetical protein -
MY052_RS15505 (MY052_15505) 3237014..3237448 + 435 WP_248537366.1 hypothetical protein -
MY052_RS15510 (MY052_15510) 3237516..3238067 + 552 WP_248537367.1 DUF4234 domain-containing protein -
MY052_RS15515 (MY052_15515) 3238186..3239004 + 819 WP_248537368.1 DUF932 domain-containing protein -
MY052_RS15520 (MY052_15520) 3239145..3239609 + 465 WP_248537369.1 antirestriction protein -
MY052_RS15525 (MY052_15525) 3239620..3240099 + 480 WP_248537370.1 DNA repair protein RadC -
MY052_RS15530 (MY052_15530) 3240114..3240335 + 222 WP_248537371.1 DUF987 domain-containing protein -
MY052_RS15535 (MY052_15535) 3240362..3240715 + 354 WP_248537372.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MY052_RS15540 (MY052_15540) 3240764..3241141 + 378 WP_248537373.1 TA system toxin CbtA family protein Toxin
MY052_RS15545 (MY052_15545) 3241138..3241629 + 492 WP_248537374.1 DUF5983 family protein -
MY052_RS15550 (MY052_15550) 3241662..3241865 + 204 WP_248537375.1 hypothetical protein -
MY052_RS15555 (MY052_15555) 3241937..3242785 + 849 WP_248537376.1 DUF4942 domain-containing protein -
MY052_RS15565 (MY052_15565) 3243150..3244769 - 1620 WP_202216117.1 ABC transporter substrate-binding protein -
MY052_RS15570 (MY052_15570) 3245007..3245666 + 660 WP_052284078.1 FtsH protease modulator YccA -
MY052_RS15575 (MY052_15575) 3245754..3246083 + 330 WP_202216118.1 sulfurtransferase TusE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(14-112)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14001.07 Da        Isoelectric Point: 9.8955

>T242860 WP_248537373.1 NZ_CP096201:3240764-3241141 [Kluyvera ascorbata]
MQILSAPPARAALSRPSPVAVWQILLSHLLAQHYGLTLNDTPFSDETIIRKHIDAGISLSDAVNFIVEKYELVRTDRHGS
TVAEQSPFISSIDMFHARRATGLMKRRGYKTISNIITGVYRQEQP

Download         Length: 378 bp

>T242860 NZ_OW967966:2880743-2880850 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 118 a.a.        Molecular weight: 13014.91 Da        Isoelectric Point: 6.9558

>AT242860 WP_248537372.1 NZ_CP096201:3240362-3240715 [Kluyvera ascorbata]
MKKDTVNKTTDTLQWGLKCDITPHFGARLVLEGNRLHYLADRASITGAFSEADLRHLDQAFPVLLKQLELMLTSGELNPR
HQHTVTLYAKGLTCEADTLGSCGYVYLAIYPTFTTAT

Download         Length: 354 bp

>AT242860 NZ_OW967966:c2880693-2880636 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References