Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1370849..1371483 Replicon chromosome
Accession NZ_CP096201
Organism Kluyvera ascorbata strain SK

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MY052_RS06490 Protein ID WP_248538393.1
Coordinates 1371079..1371483 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MY052_RS06485 Protein ID WP_248538392.1
Coordinates 1370849..1371079 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY052_RS06470 (MY052_06470) 1366053..1367429 - 1377 WP_248538390.1 exodeoxyribonuclease VII large subunit -
MY052_RS06475 (MY052_06475) 1367590..1369056 + 1467 WP_035891430.1 IMP dehydrogenase -
MY052_RS06480 (MY052_06480) 1369125..1370702 + 1578 WP_248538391.1 glutamine-hydrolyzing GMP synthase -
MY052_RS06485 (MY052_06485) 1370849..1371079 + 231 WP_248538392.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MY052_RS06490 (MY052_06490) 1371079..1371483 + 405 WP_248538393.1 tRNA(fMet)-specific endonuclease VapC Toxin
MY052_RS06495 (MY052_06495) 1371480..1371995 - 516 WP_248538394.1 GNAT family N-acetyltransferase -
MY052_RS06500 (MY052_06500) 1372001..1373194 - 1194 WP_248538395.1 MFS transporter -
MY052_RS06505 (MY052_06505) 1373267..1374179 + 913 Protein_1272 LysR family transcriptional regulator -
MY052_RS06510 (MY052_06510) 1374198..1375076 - 879 WP_035891439.1 small-conductance mechanosensitive channel MscS -
MY052_RS06515 (MY052_06515) 1375440..1375643 - 204 WP_072011319.1 YfgG family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-53)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14942.28 Da        Isoelectric Point: 7.8433

>T242850 WP_248538393.1 NZ_CP096201:1371079-1371483 [Kluyvera ascorbata]
MLKYMLDTNICIYTIKNKPQAVREAFTQHYGRMCISSVTLMELIYGAEKSAAPEKNLRVVEGFVARLEVLNYGNDAAIQT
GQIRAELAKAGTPIGPYDSMIAAHARSLGLIMVTNNTREFERISGLRLEDWSIS

Download         Length: 405 bp

>T242850 NZ_OW967966:833291-833587 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8599.63 Da        Isoelectric Point: 4.7672

>AT242850 WP_248538392.1 NZ_CP096201:1370849-1371079 [Kluyvera ascorbata]
MEKTTIFKSNRSQAVRLPKAVAMPEDVKHVDIIAIGRTRVITPAGESWDSWFDGESVTSDFMATREQPGEQDRETF

Download         Length: 231 bp

>AT242850 NZ_OW967966:833589-833984 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References