Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 1197321..1197988 | Replicon | chromosome |
| Accession | NZ_CP096201 | ||
| Organism | Kluyvera ascorbata strain SK | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A2I8SC83 |
| Locus tag | MY052_RS05755 | Protein ID | WP_054626383.1 |
| Coordinates | 1197321..1197650 (-) | Length | 110 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A2I8SA04 |
| Locus tag | MY052_RS05760 | Protein ID | WP_054626382.1 |
| Coordinates | 1197671..1197988 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MY052_RS05735 (MY052_05735) | 1194397..1195299 | + | 903 | WP_035894642.1 | lipid A hydroxylase LpxO | - |
| MY052_RS05740 (MY052_05740) | 1195524..1195856 | + | 333 | WP_035894643.1 | DUF1971 domain-containing protein | - |
| MY052_RS05745 (MY052_05745) | 1195867..1196205 | + | 339 | WP_248538355.1 | DUF1869 domain-containing protein | - |
| MY052_RS05750 (MY052_05750) | 1196418..1196954 | + | 537 | WP_202217349.1 | hypothetical protein | - |
| MY052_RS05755 (MY052_05755) | 1197321..1197650 | - | 330 | WP_054626383.1 | TA system toxin CbtA family protein | Toxin |
| MY052_RS05760 (MY052_05760) | 1197671..1197988 | - | 318 | WP_054626382.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| MY052_RS05765 (MY052_05765) | 1198006..1198227 | - | 222 | WP_054626381.1 | DUF987 domain-containing protein | - |
| MY052_RS05770 (MY052_05770) | 1198236..1198712 | - | 477 | WP_054626380.1 | RadC family protein | - |
| MY052_RS05775 (MY052_05775) | 1198728..1199186 | - | 459 | WP_049606139.1 | antirestriction protein | - |
| MY052_RS05780 (MY052_05780) | 1199270..1199509 | - | 240 | WP_054626379.1 | DUF905 domain-containing protein | - |
| MY052_RS05785 (MY052_05785) | 1199609..1200517 | - | 909 | WP_248538356.1 | Ivy family c-type lysozyme inhibitor | - |
| MY052_RS05790 (MY052_05790) | 1200586..1200753 | - | 168 | Protein_1134 | DUF4339 domain-containing protein | - |
| MY052_RS05795 (MY052_05795) | 1200791..1201486 | - | 696 | WP_054626378.1 | hypothetical protein | - |
| MY052_RS05800 (MY052_05800) | 1201713..1202540 | - | 828 | WP_054626377.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1196421..1224068 | 27647 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12324.29 Da Isoelectric Point: 7.1642
>T242849 WP_054626383.1 NZ_CP096201:c1197650-1197321 [Kluyvera ascorbata]
MKTLPATTPQAAKLCLPPVAVWQMLLTRLLETHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDRNGF
SWQEQTPYISVVDILRARRSTGLLKNNVK
MKTLPATTPQAAKLCLPPVAVWQMLLTRLLETHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVEKYELVRIDRNGF
SWQEQTPYISVVDILRARRSTGLLKNNVK
Download Length: 330 bp
>T242849 NZ_OW967966:c709055-708591 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTACAGCGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAGACAGAAGAAACCCATTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11741.53 Da Isoelectric Point: 7.0161
>AT242849 WP_054626382.1 NZ_CP096201:c1197988-1197671 [Kluyvera ascorbata]
MSKITWGLQRNITPHLGARLVQEGNRLHYLADRASITGKISDAECLKLDVAFPHFISQMELMLTTGEMNPCHAHCVILYH
NGFTCEADTLGSCGYVYVAVYPTQR
MSKITWGLQRNITPHLGARLVQEGNRLHYLADRASITGKISDAECLKLDVAFPHFISQMELMLTTGEMNPCHAHCVILYH
NGFTCEADTLGSCGYVYVAVYPTQR
Download Length: 318 bp
>AT242849 NZ_OW967966:c709390-709055 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I8SC83 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I8SA04 |