Detailed information of TA system TA242848

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 904171..904832
• Replicon: chromosome
• Accession: NZ_CP096201
• Organism: Kluyvera ascorbata strain SK

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: MY052_RS04375
• Protein ID: WP_248188259.1
• Coordinates: 904509..904832 (+)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: MY052_RS04370
• Protein ID: WP_248538264.1
• Coordinates: 904171..904488 (+)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MY052_RS04345 (MY052_04345)	899385..902537	+	3153	WP_248538896.1	AIDA repeat-containing protein	-
MY052_RS04350 (MY052_04350)	902648..902869	+	222	WP_248538897.1	DUF905 domain-containing protein	-
MY052_RS04355 (MY052_04355)	902972..903430	+	459	WP_020324813.1	antirestriction protein	-
MY052_RS04360 (MY052_04360)	903446..903922	+	477	WP_020324797.1	RadC family protein	-
MY052_RS04365 (MY052_04365)	903931..904152	+	222	WP_048997881.1	DUF987 domain-containing protein	-
MY052_RS04370 (MY052_04370)	904171..904488	+	318	WP_248538264.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MY052_RS04375 (MY052_04375)	904509..904832	+	324	WP_248188259.1	TA system toxin CbtA family protein	Toxin
MY052_RS04380 (MY052_04380)	905506..905985	-	480	Protein_860	hypothetical protein	-
MY052_RS04385 (MY052_04385)	906401..907273	+	873	WP_248538265.1	hypothetical protein	-
MY052_RS04390 (MY052_04390)	907542..908318	-	777	WP_248538266.1	SDR family oxidoreductase	-
MY052_RS04395 (MY052_04395)	908941..909636	+	696	WP_035896500.1	oligogalacturonate-specific porin KdgM family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	881777..907510	25733

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-107)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12412.29 Da
• Isoelectric Point: 5.6981

>T242848 WP_248188259.1 NZ_CP096201:904509-904832 [Kluyvera ascorbata]
MKSQPATTQRAAKPCLSPVDVWQMLLTRLLEQHYGLTLNDTPFSEERVIQEHIDAGITLADAINFLVEKYELVRIDRRGF
SWQEQTPYLTIIDIMRARLDLGLLNRN

Nucleotide

• Length: 324 bp

>T242848 NZ_OW967966:281180-281287 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 12007.67 Da
• Isoelectric Point: 7.6977

>AT242848 WP_248538264.1 NZ_CP096201:904171-904488 [Kluyvera ascorbata]
MSNITWGLQRDITPRLGARLVQEGNRLHYLAERASITGQFSDAECRKLDVAFPYFIRQMESMLTTGELNPRHTHCVTLYR
NGFTCEADTLGSCGYVYIAIYPTQR

Nucleotide

• Length: 318 bp

>AT242848 NZ_OW967966:c281123-281068 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT