Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 868561..869224 Replicon chromosome
Accession NZ_CP096201
Organism Kluyvera ascorbata strain SK

Toxin (Protein)


Gene name cptA Uniprot ID A0A378GLI7
Locus tag MY052_RS04175 Protein ID WP_035895554.1
Coordinates 868808..869224 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag MY052_RS04170 Protein ID WP_248538250.1
Coordinates 868561..868827 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MY052_RS04145 (MY052_04145) 863760..865193 - 1434 WP_248538248.1 6-phospho-beta-glucosidase -
MY052_RS04150 (MY052_04150) 865314..866042 - 729 WP_035895546.1 MurR/RpiR family transcriptional regulator -
MY052_RS04155 (MY052_04155) 866094..866408 + 315 WP_035895547.1 N(4)-acetylcytidine aminohydrolase -
MY052_RS04160 (MY052_04160) 866567..867229 + 663 WP_248538249.1 hemolysin III family protein -
MY052_RS04165 (MY052_04165) 867330..868313 - 984 WP_202217207.1 tRNA-modifying protein YgfZ -
MY052_RS04170 (MY052_04170) 868561..868827 + 267 WP_248538250.1 FAD assembly factor SdhE Antitoxin
MY052_RS04175 (MY052_04175) 868808..869224 + 417 WP_035895554.1 protein YgfX Toxin
MY052_RS04180 (MY052_04180) 869221..869742 - 522 WP_035895556.1 flavodoxin FldB -
MY052_RS04185 (MY052_04185) 869845..870741 + 897 WP_035895558.1 site-specific tyrosine recombinase XerD -
MY052_RS04190 (MY052_04190) 870764..871477 + 714 WP_248538251.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MY052_RS04195 (MY052_04195) 871483..873216 + 1734 WP_248538252.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16515.47 Da        Isoelectric Point: 11.4884

>T242847 WP_035895554.1 NZ_CP096201:868808-869224 [Kluyvera ascorbata]
VVLWQSDLRVSWRSQWLSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSLVVFDCVRSQRRIHSHQGEIKLLMDSRLRWRNQ
DYELLGAPWMLNSGMMLRIRRLEGGRRQHLWLAADSMNPEEWRDLRRILLQQPTPTKH

Download         Length: 417 bp

>T242847 NZ_OW967966:280696-280803 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10484.00 Da        Isoelectric Point: 4.8432

>AT242847 WP_248538250.1 NZ_CP096201:868561-868827 [Kluyvera ascorbata]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDEDKAIFIRLLECDDPDLFNWLMNHGKPADANLERMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT242847 NZ_OW967966:c280647-280584 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378GLI7

Antitoxin

Source ID Structure

References