Detailed information of TA system TA242843

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 1049328..1049893
• Replicon: chromosome
• Accession: NZ_CP096200
• Organism: Vibrio sinaloensis strain YA2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MTO69_RS18265
• Protein ID: WP_248334836.1
• Coordinates: 1049606..1049893 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3BLE1
• Locus tag: MTO69_RS18260
• Protein ID: WP_000086647.1
• Coordinates: 1049328..1049609 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTO69_RS18240 (MTO69_18240)	1047247..1047555	+	309	WP_004413754.1	transposase	-
MTO69_RS18245 (MTO69_18245)	1047552..1048403	+	852	WP_248334819.1	IS3 family transposase	-
MTO69_RS18250 (MTO69_18250)	1048487..1048783	-	297	WP_248334835.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MTO69_RS18255 (MTO69_18255)	1048790..1049032	-	243	WP_045957228.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MTO69_RS18260 (MTO69_18260)	1049328..1049609	+	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MTO69_RS18265 (MTO69_18265)	1049606..1049893	+	288	WP_248334836.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MTO69_RS18270 (MTO69_18270)	1050148..1050576	+	429	Protein_925	GNAT family N-acetyltransferase	-
MTO69_RS18275 (MTO69_18275)	1050767..1051075	+	309	WP_004413754.1	transposase	-
MTO69_RS18280 (MTO69_18280)	1051393..1052154	+	762	WP_248334837.1	CDP-alcohol phosphatidyltransferase family protein	-
MTO69_RS18285 (MTO69_18285)	1052147..1053079	+	933	WP_248334838.1	phosphatidate cytidylyltransferase	-
MTO69_RS18290 (MTO69_18290)	1053089..1053733	+	645	WP_248334839.1	lysophospholipid acyltransferase family protein	-
MTO69_RS18295 (MTO69_18295)	1053928..1054452	+	525	WP_248334840.1	DUF4823 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1014250..1051075	36825

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11025.71 Da
• Isoelectric Point: 5.1098

>T242843 WP_248334836.1 NZ_CP096200:1049606-1049893 [Vibrio sinaloensis]
MKVVWSPLALQKLGDAAEFISLDNPSAAEKWVNEVFDKTELLGSMPEMGRFVPEMPHTNYREIIFGHYRIIYSLTHEIRV
LTVRNCRQMLSEDDV

Nucleotide

• Length: 288 bp

>T242843 NZ_OW967803:107026-107406 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTAGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10398.91 Da
• Isoelectric Point: 5.8650

>AT242843 WP_000086647.1 NZ_CP096200:1049328-1049609 [Vibrio sinaloensis]
MSRIHFDQDIQPLSEFRAGVASYIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
DDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT242843 NZ_OW967803:106805-107026 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Antitoxin

• AlphaFold DB: A0A4P8G0X0