Detailed information of TA system TA242842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1048487..1049032
• Replicon: chromosome
• Accession: NZ_CP096200
• Organism: Vibrio sinaloensis strain YA2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MTO69_RS18250
• Protein ID: WP_248334835.1
• Coordinates: 1048487..1048783 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A4U2ER13
• Locus tag: MTO69_RS18255
• Protein ID: WP_045957228.1
• Coordinates: 1048790..1049032 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTO69_RS18230 (MTO69_18230)	1043526..1043954	+	429	WP_248334833.1	GNAT family N-acetyltransferase	-
MTO69_RS18235 (MTO69_18235)	1044093..1044515	+	423	WP_248334834.1	GNAT family N-acetyltransferase	-
MTO69_RS18240 (MTO69_18240)	1047247..1047555	+	309	WP_004413754.1	transposase	-
MTO69_RS18245 (MTO69_18245)	1047552..1048403	+	852	WP_248334819.1	IS3 family transposase	-
MTO69_RS18250 (MTO69_18250)	1048487..1048783	-	297	WP_248334835.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MTO69_RS18255 (MTO69_18255)	1048790..1049032	-	243	WP_045957228.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MTO69_RS18260 (MTO69_18260)	1049328..1049609	+	282	WP_000086647.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MTO69_RS18265 (MTO69_18265)	1049606..1049893	+	288	WP_248334836.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MTO69_RS18270 (MTO69_18270)	1050148..1050576	+	429	Protein_925	GNAT family N-acetyltransferase	-
MTO69_RS18275 (MTO69_18275)	1050767..1051075	+	309	WP_004413754.1	transposase	-
MTO69_RS18280 (MTO69_18280)	1051393..1052154	+	762	WP_248334837.1	CDP-alcohol phosphatidyltransferase family protein	-
MTO69_RS18285 (MTO69_18285)	1052147..1053079	+	933	WP_248334838.1	phosphatidate cytidylyltransferase	-
MTO69_RS18290 (MTO69_18290)	1053089..1053733	+	645	WP_248334839.1	lysophospholipid acyltransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1014250..1051075	36825

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-63)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11218.88 Da
• Isoelectric Point: 9.6944

>T242842 WP_248334835.1 NZ_CP096200:c1048783-1048487 [Vibrio sinaloensis]
MQKNKYKLSKLAQAHLRKIKSYTVNNFSEMQWNNYKDTLLTGFQMLADNPAVGRSCDEIYPSGFFFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T242842 NZ_OW967803:94388-94804 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8947.14 Da
• Isoelectric Point: 4.7914

>AT242842 WP_045957228.1 NZ_CP096200:c1049032-1048790 [Vibrio sinaloensis]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLKHCFESAKQDLAQGNVVDGEDFLSAL

Nucleotide

• Length: 243 bp

>AT242842 NZ_OW967803:94161-94391 [Escherichia coli]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A4U2ER13