Detailed information of TA system TA242841

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1040473..1041020
• Replicon: chromosome
• Accession: NZ_CP096200
• Organism: Vibrio sinaloensis strain YA2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MTO69_RS18200
• Protein ID: WP_248334831.1
• Coordinates: 1040718..1041020 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MTO69_RS18195
• Protein ID: WP_248334830.1
• Coordinates: 1040473..1040730 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTO69_RS18165 (MTO69_18165)	1035936..1036301	+	366	WP_248334828.1	VOC family protein	-
MTO69_RS18170 (MTO69_18170)	1036445..1036816	+	372	WP_049877282.1	hypothetical protein	-
MTO69_RS18175 (MTO69_18175)	1037007..1037315	+	309	WP_004413754.1	transposase	-
MTO69_RS18180 (MTO69_18180)	1037312..1038163	+	852	WP_248334819.1	IS3 family transposase	-
MTO69_RS18185 (MTO69_18185)	1038767..1039246	+	480	WP_248334829.1	GNAT family N-acetyltransferase	-
MTO69_RS18190 (MTO69_18190)	1039851..1040282	+	432	WP_136678155.1	GNAT family N-acetyltransferase	-
MTO69_RS18195 (MTO69_18195)	1040473..1040730	+	258	WP_248334830.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MTO69_RS18200 (MTO69_18200)	1040718..1041020	+	303	WP_248334831.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MTO69_RS18205 (MTO69_18205)	1041173..1041619	+	447	WP_248334832.1	GNAT family N-acetyltransferase	-
MTO69_RS18210 (MTO69_18210)	1041806..1042114	+	309	WP_039453493.1	transposase	-
MTO69_RS18215 (MTO69_18215)	1042111..1042962	+	852	WP_248334825.1	IS3 family transposase	-
MTO69_RS18225 (MTO69_18225)	1043380..1043490	+	111	WP_248335615.1	DUF3265 domain-containing protein	-
MTO69_RS18230 (MTO69_18230)	1043526..1043954	+	429	WP_248334833.1	GNAT family N-acetyltransferase	-
MTO69_RS18235 (MTO69_18235)	1044093..1044515	+	423	WP_248334834.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1014250..1051075	36825

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11669.57 Da
• Isoelectric Point: 5.1765

>T242841 WP_248334831.1 NZ_CP096200:1040718-1041020 [Vibrio sinaloensis]
MVEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FVLFVMRAERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T242841 NZ_OW967803:c87987-87682 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTCTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9592.07 Da
• Isoelectric Point: 6.7269

>AT242841 WP_248334830.1 NZ_CP096200:1040473-1040730 [Vibrio sinaloensis]
MKVELVTSLKRQATKILADLHDSKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT242841 NZ_OW967803:c88207-87989 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATACAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA