Detailed information of TA system TA242839

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1019213..1019758
• Replicon: chromosome
• Accession: NZ_CP096200
• Organism: Vibrio sinaloensis strain YA2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MTO69_RS18065
• Protein ID: WP_077281733.1
• Coordinates: 1019213..1019509 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: MTO69_RS18070
• Protein ID: WP_080608911.1
• Coordinates: 1019516..1019758 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTO69_RS18050 (MTO69_18050)	1014250..1015212	-	963	WP_248334816.1	integron integrase	-
MTO69_RS18055 (MTO69_18055)	1015486..1015854	+	369	WP_248334817.1	VOC family protein	-
MTO69_RS18060 (MTO69_18060)	1018152..1019045	+	894	WP_248334818.1	hypothetical protein	-
MTO69_RS18065 (MTO69_18065)	1019213..1019509	-	297	WP_077281733.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MTO69_RS18070 (MTO69_18070)	1019516..1019758	-	243	WP_080608911.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MTO69_RS18075 (MTO69_18075)	1020046..1020354	+	309	WP_004413754.1	transposase	-
MTO69_RS18080 (MTO69_18080)	1020351..1021202	+	852	WP_248334819.1	IS3 family transposase	-
MTO69_RS18085 (MTO69_18085)	1021251..1021634	+	384	WP_248334820.1	hypothetical protein	-
MTO69_RS18090 (MTO69_18090)	1021704..1021865	+	162	WP_248334821.1	hypothetical protein	-
MTO69_RS18095 (MTO69_18095)	1022332..1022700	+	369	WP_248334822.1	VOC family protein	-
MTO69_RS18100 (MTO69_18100)	1022907..1023215	+	309	WP_004413754.1	transposase	-
MTO69_RS18105 (MTO69_18105)	1023212..1024063	+	852	WP_248334819.1	IS3 family transposase	-
MTO69_RS18110 (MTO69_18110)	1024104..1024394	-	291	WP_005377002.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MTO69_RS18115 (MTO69_18115)	1024384..1024632	-	249	WP_005377003.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1014250..1051075	36825
	-	inside	Genomic island	-	-	1015486..1028010	12524

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11332.00 Da
• Isoelectric Point: 9.8645

>T242839 WP_077281733.1 NZ_CP096200:c1019509-1019213 [Vibrio sinaloensis]
MQKNKYKLSKLAQAHLRKIRSYTVNNFSEMQWRNYKDTLLTGFQMLADNPAVGRSCDEIYPNGFYFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL

Nucleotide

• Length: 297 bp

>T242839 NZ_OW967802:c4223754-4223581 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8988.15 Da
• Isoelectric Point: 4.7914

>AT242839 WP_080608911.1 NZ_CP096200:c1019758-1019516 [Vibrio sinaloensis]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIRDYEELEAMKADYLKHCFESAKQDLAQGNVVDGEDFLNSL

Nucleotide

• Length: 243 bp

>AT242839 NZ_OW967802:c4224078-4223782 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG