Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 23508..24034 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP096189 | ||
| Organism | Enterobacter roggenkampii isolate C3-17 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | M0769_RS23665 | Protein ID | WP_000323025.1 |
| Coordinates | 23747..24034 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | M0769_RS23660 | Protein ID | WP_000534858.1 |
| Coordinates | 23508..23747 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - (20622) | 20622..20746 | + | 125 | NuclAT_0 | - | - |
| - (20622) | 20622..20746 | + | 125 | NuclAT_0 | - | - |
| - (20622) | 20622..20746 | + | 125 | NuclAT_0 | - | - |
| - (20622) | 20622..20746 | + | 125 | NuclAT_0 | - | - |
| M0769_RS23640 (20732) | 20732..20797 | + | 66 | WP_157844161.1 | DUF5431 family protein | - |
| M0769_RS23645 (20866) | 20866..22206 | + | 1341 | WP_004196353.1 | IS1202-like element ISEsa1 family transposase | - |
| M0769_RS23650 (22643) | 22643..22975 | - | 333 | WP_001317460.1 | FlxA-like family protein | - |
| M0769_RS23655 (23178) | 23178..23483 | - | 306 | WP_001326990.1 | protein YdfV | - |
| M0769_RS23660 (23508) | 23508..23747 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| M0769_RS23665 (23747) | 23747..24034 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| M0769_RS23670 (24106) | 24106..24264 | + | 159 | WP_008325141.1 | type I toxin-antitoxin system Hok family toxin | - |
| M0769_RS23675 (25139) | 25139..25432 | + | 294 | WP_023327733.1 | hypothetical protein | - |
| M0769_RS23680 (25449) | 25449..26270 | + | 822 | WP_023327732.1 | DUF932 domain-containing protein | - |
| M0769_RS23685 (26299) | 26299..26838 | - | 540 | WP_032636190.1 | lytic transglycosylase domain-containing protein | - |
| M0769_RS23690 (27412) | 27412..27807 | + | 396 | WP_023327730.1 | hypothetical protein | - |
| M0769_RS23695 (27840) | 27840..28481 | - | 642 | WP_032636186.1 | Arc family DNA-binding protein | - |
| M0769_RS23700 (28678) | 28678..29031 | + | 354 | WP_033147099.1 | type IV conjugative transfer system pilin TraA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..76094 | 76094 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T242838 WP_000323025.1 NZ_CP096189:23747-24034 [Enterobacter roggenkampii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T242838 NZ_OW967802:3497139-3497357 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT242838 WP_000534858.1 NZ_CP096189:23508-23747 [Enterobacter roggenkampii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT242838 NZ_OW967802:3496739-3497113 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|