Detailed information of TA system TA242826

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1077467..1078087
• Replicon: chromosome
• Accession: NZ_CP096187
• Organism: Enterobacter roggenkampii isolate C3-17

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A1H8SI38
• Locus tag: M0769_RS05100
• Protein ID: WP_008499287.1
• Coordinates: 1077467..1077685 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: M0769_RS05105
• Protein ID: WP_181530683.1
• Coordinates: 1077713..1078087 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0769_RS05070 (M0769_05070)	1073480..1073740	+	261	WP_006176933.1	type B 50S ribosomal protein L31	-
M0769_RS05075 (M0769_05075)	1073743..1073883	+	141	WP_034458060.1	type B 50S ribosomal protein L36	-
M0769_RS05080 (M0769_05080)	1073880..1074590	-	711	WP_181530684.1	GNAT family protein	-
M0769_RS05085 (M0769_05085)	1074692..1076152	+	1461	WP_161622866.1	PLP-dependent aminotransferase family protein	-
M0769_RS05090 (M0769_05090)	1076124..1076591	-	468	WP_008499285.1	YlaC family protein	-
M0769_RS05095 (M0769_05095)	1076709..1077260	-	552	WP_008499286.1	maltose O-acetyltransferase	-
M0769_RS05100 (M0769_05100)	1077467..1077685	-	219	WP_008499287.1	HHA domain-containing protein	Toxin
M0769_RS05105 (M0769_05105)	1077713..1078087	-	375	WP_181530683.1	Hha toxicity modulator TomB	Antitoxin
M0769_RS05110 (M0769_05110)	1078597..1081743	-	3147	WP_008499289.1	multidrug efflux RND transporter permease subunit AcrB	-
M0769_RS05115 (M0769_05115)	1081766..1082959	-	1194	WP_021241633.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8612.00 Da
• Isoelectric Point: 8.9008

>T242826 WP_008499287.1 NZ_CP096187:c1077685-1077467 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Nucleotide

• Length: 219 bp

>T242826 NZ_OW967802:903812-904219 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14481.32 Da
• Isoelectric Point: 5.1625

>AT242826 WP_181530683.1 NZ_CP096187:c1078087-1077713 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAKDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Nucleotide

• Length: 375 bp

>AT242826 NZ_OW967802:903565-903831 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A1H8SI38