Detailed information of TA system TA242824

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 525367..525883
• Replicon: chromosome
• Accession: NZ_CP096187
• Organism: Enterobacter roggenkampii isolate C3-17

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: M0769_RS02515
• Protein ID: WP_123922983.1
• Coordinates: 525599..525883 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: V3EXX3
• Locus tag: M0769_RS02510
• Protein ID: WP_008501400.1
• Coordinates: 525367..525609 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0769_RS02495 (M0769_02495)	521457..522197	+	741	WP_181530859.1	KDGP aldolase family protein	-
M0769_RS02500 (M0769_02500)	522223..523359	+	1137	WP_063616763.1	lactonase family protein	-
M0769_RS02505 (M0769_02505)	523379..525289	+	1911	WP_008501401.1	PRD domain-containing protein	-
M0769_RS02510 (M0769_02510)	525367..525609	+	243	WP_008501400.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
M0769_RS02515 (M0769_02515)	525599..525883	+	285	WP_123922983.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M0769_RS02520 (M0769_02520)	525887..526351	-	465	WP_045408172.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
M0769_RS02525 (M0769_02525)	526457..528595	-	2139	WP_070533959.1	anaerobic ribonucleoside-triphosphate reductase	-
M0769_RS02530 (M0769_02530)	528972..530615	-	1644	WP_123922985.1	alpha,alpha-phosphotrehalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10691.49 Da
• Isoelectric Point: 10.3039

>T242824 WP_123922983.1 NZ_CP096187:525599-525883 [Enterobacter roggenkampii]
MTYELEFDPRALKEWSKLGDTVKNQFKKKLAGVLANPRVESARLHGLPDCYKIKLKASGYRLIYQVQDSVITVLVIAVGK
REKSAAYHDANKRL

Nucleotide

• Length: 285 bp

>T242824 NZ_OW967802:c656620-656156 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8972.37 Da
• Isoelectric Point: 5.0651

>AT242824 WP_008501400.1 NZ_CP096187:525367-525609 [Enterobacter roggenkampii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Nucleotide

• Length: 243 bp

>AT242824 NZ_OW967802:c656955-656620 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: V3EXX3