Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 4427309..4428105 Replicon chromosome
Accession NZ_CP096169
Organism Shewanella sp. JNE2

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MZ182_RS19620 Protein ID WP_115016818.1
Coordinates 4427309..4427839 (-) Length 177 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6N3J9J2
Locus tag MZ182_RS19625 Protein ID WP_011791159.1
Coordinates 4427836..4428105 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZ182_RS19600 (MZ182_19600) 4423636..4424403 - 768 WP_011918338.1 class I SAM-dependent methyltransferase -
MZ182_RS19605 (MZ182_19605) 4424678..4425451 + 774 WP_011918337.1 hypothetical protein -
MZ182_RS19610 (MZ182_19610) 4425726..4426196 + 471 WP_248066743.1 hypothetical protein -
MZ182_RS19615 (MZ182_19615) 4426316..4427008 + 693 WP_248066744.1 hypothetical protein -
MZ182_RS19620 (MZ182_19620) 4427309..4427839 - 531 WP_115016818.1 GNAT family N-acetyltransferase Toxin
MZ182_RS19625 (MZ182_19625) 4427836..4428105 - 270 WP_011791159.1 DUF1778 domain-containing protein Antitoxin
MZ182_RS19630 (MZ182_19630) 4428308..4428874 - 567 WP_181811409.1 SEC-C metal-binding domain-containing protein -
MZ182_RS19635 (MZ182_19635) 4429409..4429792 - 384 WP_248066747.1 GIY-YIG nuclease family protein -
MZ182_RS19640 (MZ182_19640) 4429803..4431938 - 2136 WP_248066748.1 S9 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(97-153)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 19767.10 Da        Isoelectric Point: 8.3330

>T242819 WP_115016818.1 NZ_CP096169:c4427839-4427309 [Shewanella sp. JNE2]
VSYSKIFKELDKSLHDRASFDCGEAELNDFIQTQAAKHMQAGISRTMVLPAAMPLPNQKYPICSFYTIAPSSICRDTLPQ
AIGKKLPRYPIPVFLLAQLAVHKEFHGSGLGKASLIKALEYLWEINAHMRAYAIVVDCLTDQAESFYAKYGFEVLCEING
RVRMFIPMKTVGQLFT

Download         Length: 531 bp

>T242819 NZ_OW967796:c86170-86021 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9859.32 Da        Isoelectric Point: 4.7037

>AT242819 WP_011791159.1 NZ_CP096169:c4428105-4427836 [Shewanella sp. JNE2]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDATQVIAEHESVTVKADVFDQFIMACDEAKVPNKALREAA
AFTKNGEFK

Download         Length: 270 bp

>AT242819 NZ_OW967796:86214-86275 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6N3J9J2

References