Detailed information of TA system TA242815

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazF-chpS/PRK09907-MazE
• Location: 2916121..2916704
• Replicon: chromosome
• Accession: NZ_CP096169
• Organism: Shewanella sp. JNE2

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A448CPD5
• Locus tag: MZ182_RS13005
• Protein ID: WP_014610905.1
• Coordinates: 2916121..2916450 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: -
• Locus tag: MZ182_RS13010
• Protein ID: WP_086904821.1
• Coordinates: 2916450..2916704 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZ182_RS12985 (MZ182_12985)	2912755..2914005	-	1251	WP_248069812.1	type II toxin-antitoxin system HipA family toxin	-
MZ182_RS12990 (MZ182_12990)	2914002..2914307	-	306	WP_004249763.1	helix-turn-helix domain-containing protein	-
MZ182_RS12995 (MZ182_12995)	2914591..2915321	+	731	Protein_2509	IS3 family transposase	-
MZ182_RS13000 (MZ182_13000)	2915642..2915991	-	350	Protein_2510	helix-turn-helix domain-containing protein	-
MZ182_RS13005 (MZ182_13005)	2916121..2916450	-	330	WP_014610905.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MZ182_RS13010 (MZ182_13010)	2916450..2916704	-	255	WP_086904821.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
MZ182_RS13015 (MZ182_13015)	2917090..2918547	+	1458	WP_248069810.1	gamma-mobile-trio recombinase GmtY	-
MZ182_RS13020 (MZ182_13020)	2918547..2921219	+	2673	WP_119565105.1	integrase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-107)

Antitoxin

• SpoVT-AbrB domain (6-46)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12058.97 Da
• Isoelectric Point: 8.9492

>T242815 WP_014610905.1 NZ_CP096169:c2916450-2916121 [Shewanella sp. JNE2]
MSYTPKRGDIVWIDFDPSAGHEQAHHRPALVLSPEPFNKQIQLALVAPITSRVRGHGFEVAVDTDKTKGVVLCQQVKTID
YAARDVKYIEKAPVAVLNEVLAKVRVLVS

Nucleotide

• Length: 330 bp

>T242815 NZ_OW967795:3974244-3974582 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGCCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTACCA
CCGGCACGGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAAGAGAGCGAA
CTGATGCAGTCACTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGATTTTATTGGGGTGATTAG
TAGCAAAACGCCACGCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8922.19 Da
• Isoelectric Point: 4.3021

>AT242815 WP_086904821.1 NZ_CP096169:c2916704-2916450 [Shewanella sp. JNE2]
MQTSIKKWGNSAGAIIPAAVLKKAGFGMGDQVEIEVVQGRIVMSPATPIFTLDELLSASPKGSFELDSEDTQWLSSSPVG
KEEI

Nucleotide

• Length: 255 bp

>AT242815 NZ_OW967795:c3974249-3974173 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A448CPD5