Detailed information of TA system TA242811

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 298815..299365
• Replicon: chromosome
• Accession: NZ_CP096169
• Organism: Shewanella sp. JNE2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MZ182_RS01430
• Protein ID: WP_014609651.1
• Coordinates: 298815..299114 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A6N3J071
• Locus tag: MZ182_RS01435
• Protein ID: WP_011787680.1
• Coordinates: 299123..299365 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZ182_RS01410 (MZ182_01410)	294679..295155	-	477	WP_248068224.1	GNAT family N-acetyltransferase	-
MZ182_RS01415 (MZ182_01415)	295668..296684	-	1017	WP_014609791.1	IS110-like element ISSpu22 family transposase	-
MZ182_RS01420 (MZ182_01420)	297260..297463	+	204	WP_061782969.1	hypothetical protein	-
MZ182_RS01425 (MZ182_01425)	297697..298563	+	867	WP_025008029.1	DUF6236 family protein	-
MZ182_RS01430 (MZ182_01430)	298815..299114	-	300	WP_014609651.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MZ182_RS01435 (MZ182_01435)	299123..299365	-	243	WP_011787680.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MZ182_RS01440 (MZ182_01440)	299843..300586	-	744	WP_248069536.1	hypothetical protein	-
MZ182_RS01445 (MZ182_01445)	300618..301877	-	1260	WP_248069538.1	beta-ketoacyl-ACP synthase	-
MZ182_RS01450 (MZ182_01450)	301878..302603	-	726	WP_248069540.1	3-ketoacyl-ACP reductase FabG2	-
MZ182_RS01455 (MZ182_01455)	302716..303249	-	534	WP_248069543.1	hotdog family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	295668..296684	1016

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-66)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11553.37 Da
• Isoelectric Point: 9.5972

>T242811 WP_014609651.1 NZ_CP096169:c299114-298815 [Shewanella sp. JNE2]
MKNKRYKLSKLAQTHLLKIKDYTIQHFSESQWHKYKESLISGLQMLADNPGLGRSCEDIYPNGFYFPIAKHTAYFTKEDD
FILIVALLGQPQLPQNHLK

Nucleotide

• Length: 300 bp

>T242811 NZ_OW967795:c3313479-3313177 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGTT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8920.14 Da
• Isoelectric Point: 5.0621

>AT242811 WP_011787680.1 NZ_CP096169:c299365-299123 [Shewanella sp. JNE2]
VQTLTANDAKRNFGELLLNAQREPIKISKNSKDAVVVMSIHDFEQLEAMKADYLKHCFNAAKEDLAKGNIVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT242811 NZ_OW967795:c3313141-3312800 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Structures

Antitoxin

• AlphaFold DB: A0A6N3J071