Detailed information of TA system TA242807

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 3061348..3062179
• Replicon: chromosome
• Accession: NZ_CP096166
• Organism: Shewanella sp. JNE7

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: -
• Locus tag: MZ097_RS13700
• Protein ID: WP_088585313.1
• Coordinates: 3061763..3062179 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: -
• Locus tag: MZ097_RS13695
• Protein ID: WP_088585314.1
• Coordinates: 3061348..3061770 (+)
• Length: 141 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZ097_RS13670 (MZ097_13670)	3057572..3057856	-	285	WP_126491562.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MZ097_RS13675 (MZ097_13675)	3057846..3058085	-	240	WP_126491561.1	CopG family ribbon-helix-helix protein	-
MZ097_RS13680 (MZ097_13680)	3058801..3060009	-	1209	WP_248084660.1	J domain-containing protein	-
MZ097_RS13685 (MZ097_13685)	3060221..3060568	-	348	WP_126491559.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MZ097_RS13690 (MZ097_13690)	3060570..3060830	-	261	WP_115017884.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MZ097_RS13695 (MZ097_13695)	3061348..3061770	+	423	WP_088585314.1	nucleotidyltransferase domain-containing protein	Antitoxin
MZ097_RS13700 (MZ097_13700)	3061763..3062179	+	417	WP_088585313.1	DUF86 domain-containing protein	Toxin
MZ097_RS13705 (MZ097_13705)	3062575..3063927	-	1353	WP_248084661.1	phosphoglucosamine mutase	-
MZ097_RS13710 (MZ097_13710)	3064002..3065942	-	1941	WP_248084662.1	nucleoside-diphosphate sugar epimerase/dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (12-130)

Antitoxin

• Polymerase beta, nucleotidyltransferase (9-96)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16056.55 Da
• Isoelectric Point: 7.3244

>T242807 WP_088585313.1 NZ_CP096166:3061763-3062179 [Shewanella sp. JNE7]
MNDIIINKIATIKRCIKRIQQVYGDGSMFKQDFTLQDSVILNLQRCCEASIDIANHINRQQQLGIPQSSRDSFTLLSQNK
IINQQLADNLKKMVGLRNIAVHDYQELNLDIVVHVVQHHLEDFEQFIEVIKFCPRMSY

Nucleotide

• Length: 417 bp

>T242807 NZ_OW967795:2053748-2053850 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 141 a.a.
• Molecular weight: 15861.89 Da
• Isoelectric Point: 5.1231

>AT242807 WP_088585314.1 NZ_CP096166:3061348-3061770 [Shewanella sp. JNE7]
MQQLNESIIINLLQDNIPQLRLIYLFGSYAQGTQHRNSDIDIAVLADVTLDNIARWQLAQKLASALDTDVDLVDLRTAST
VLCQQVVTQGKRLWGTRQDDEIFAVKTISMYQHLQAERQAIIDDATAKTTANDHRGRHFE

Nucleotide

• Length: 423 bp

>AT242807 NZ_OW967795:c2053888-2053620 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT