Detailed information of TA system TA242806

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazF-chpS/PRK09907-MazE
• Location: 3020608..3021191
• Replicon: chromosome
• Accession: NZ_CP096166
• Organism: Shewanella sp. JNE7

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A448CPD5
• Locus tag: MZ097_RS13490
• Protein ID: WP_014610905.1
• Coordinates: 3020608..3020937 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: -
• Locus tag: MZ097_RS13495
• Protein ID: WP_086904821.1
• Coordinates: 3020937..3021191 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZ097_RS13470 (MZ097_13470)	3017242..3018492	-	1251	WP_248069812.1	type II toxin-antitoxin system HipA family toxin	-
MZ097_RS13475 (MZ097_13475)	3018489..3018794	-	306	WP_004249763.1	helix-turn-helix domain-containing protein	-
MZ097_RS13480 (MZ097_13480)	3019078..3019808	+	731	Protein_2610	IS3 family transposase	-
MZ097_RS13485 (MZ097_13485)	3020129..3020478	-	350	Protein_2611	helix-turn-helix domain-containing protein	-
MZ097_RS13490 (MZ097_13490)	3020608..3020937	-	330	WP_014610905.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MZ097_RS13495 (MZ097_13495)	3020937..3021191	-	255	WP_086904821.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
MZ097_RS13500 (MZ097_13500)	3021577..3023034	+	1458	WP_248069810.1	gamma-mobile-trio recombinase GmtY	-
MZ097_RS13505 (MZ097_13505)	3023034..3025706	+	2673	WP_119565105.1	integrase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-107)

Antitoxin

• SpoVT-AbrB domain (6-46)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12058.97 Da
• Isoelectric Point: 8.9492

>T242806 WP_014610905.1 NZ_CP096166:c3020937-3020608 [Shewanella sp. JNE7]
MSYTPKRGDIVWIDFDPSAGHEQAHHRPALVLSPEPFNKQIQLALVAPITSRVRGHGFEVAVDTDKTKGVVLCQQVKTID
YAARDVKYIEKAPVAVLNEVLAKVRVLVS

Nucleotide

• Length: 330 bp

>T242806 NZ_OW967795:c1823469-1823095 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8922.19 Da
• Isoelectric Point: 4.3021

>AT242806 WP_086904821.1 NZ_CP096166:c3021191-3020937 [Shewanella sp. JNE7]
MQTSIKKWGNSAGAIIPAAVLKKAGFGMGDQVEIEVVQGRIVMSPATPIFTLDELLSASPKGSFELDSEDTQWLSSSPVG
KEEI

Nucleotide

• Length: 255 bp

>AT242806 NZ_OW967795:c1823926-1823558 [Escherichia coli]
GTGTCAGACAAACTCCATGAGACAAATTATCCCGACGACCATAACGACCGCCTCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Toxin

• AlphaFold DB: A0A448CPD5