Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ParE-CopA/ParE-RHH
Location 2010686..2011251 Replicon chromosome
Accession NZ_CP096166
Organism Shewanella sp. JNE7

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag MZ097_RS09030 Protein ID WP_248084373.1
Coordinates 2010686..2010979 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name copA Uniprot ID -
Locus tag MZ097_RS09035 Protein ID WP_115014944.1
Coordinates 2010967..2011251 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZ097_RS09005 (MZ097_09005) 2005775..2006203 + 429 WP_248084371.1 DUF86 domain-containing protein -
MZ097_RS09010 (MZ097_09010) 2006636..2007712 + 1077 WP_076500105.1 hypothetical protein -
MZ097_RS09015 (MZ097_09015) 2007857..2008069 + 213 WP_076500103.1 AlpA family phage regulatory protein -
MZ097_RS21635 2008127..2008585 + 459 WP_262918164.1 YfjI family protein -
MZ097_RS09020 (MZ097_09020) 2008611..2009663 + 1053 Protein_1751 YfjI family protein -
MZ097_RS09025 (MZ097_09025) 2009866..2010543 + 678 WP_264302493.1 inovirus Gp2 family protein -
MZ097_RS09030 (MZ097_09030) 2010686..2010979 - 294 WP_248084373.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MZ097_RS09035 (MZ097_09035) 2010967..2011251 - 285 WP_115014944.1 CopG family ribbon-helix-helix protein Antitoxin
MZ097_RS09040 (MZ097_09040) 2011536..2012258 - 723 WP_248084374.1 lecithin retinol acyltransferase family protein -
MZ097_RS09045 (MZ097_09045) 2012339..2012905 - 567 WP_028760122.1 site-specific integrase -
MZ097_RS09050 (MZ097_09050) 2013014..2013421 - 408 WP_248084375.1 DUF2787 domain-containing protein -
MZ097_RS09055 (MZ097_09055) 2013558..2013677 - 120 Protein_1758 site-specific integrase -
MZ097_RS09060 (MZ097_09060) 2013865..2013963 + 99 WP_248084376.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-44)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11139.68 Da        Isoelectric Point: 5.8404

>T242803 WP_248084373.1 NZ_CP096166:c2010979-2010686 [Shewanella sp. JNE7]
MPQIIFTATAVRDLERLREFLRTKNPPAAQRAASAIINTIRKLESYPDIGRPIDDNDFSFRELLIDFGDTGYLAMYQYDG
GERLTVLCIRHQKEAGY

Download         Length: 294 bp

>T242803 NZ_OW967795:1040800-1041135 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTATGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10941.26 Da        Isoelectric Point: 6.3342

>AT242803 WP_115014944.1 NZ_CP096166:c2011251-2010967 [Shewanella sp. JNE7]
MSTIKPVSVKLDADIKARVEHLAETRKRSSHWMMREAIREYVEREEKREALQQEALRAWEEHQTSGLHVTGDEVVSWLES
WGSENEKAAPSCHK

Download         Length: 285 bp

>AT242803 NZ_OW967795:1040552-1040800 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGCGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References