Detailed information of TA system TA242801

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 298945..299495
• Replicon: chromosome
• Accession: NZ_CP096166
• Organism: Shewanella sp. JNE7

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MZ097_RS01425
• Protein ID: WP_014609651.1
• Coordinates: 298945..299244 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A6N3J071
• Locus tag: MZ097_RS01430
• Protein ID: WP_011787680.1
• Coordinates: 299253..299495 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZ097_RS01405 (MZ097_01405)	294832..295308	-	477	WP_248068224.1	GNAT family N-acetyltransferase	-
MZ097_RS01410 (MZ097_01410)	295798..296814	-	1017	WP_248085124.1	IS110-like element ISSpu22 family transposase	-
MZ097_RS01415 (MZ097_01415)	297390..297593	+	204	WP_061782969.1	hypothetical protein	-
MZ097_RS01420 (MZ097_01420)	297827..298693	+	867	WP_025008029.1	DUF6236 family protein	-
MZ097_RS01425 (MZ097_01425)	298945..299244	-	300	WP_014609651.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MZ097_RS01430 (MZ097_01430)	299253..299495	-	243	WP_011787680.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MZ097_RS01435 (MZ097_01435)	299973..300716	-	744	WP_248069536.1	hypothetical protein	-
MZ097_RS01440 (MZ097_01440)	300748..302007	-	1260	WP_248069538.1	beta-ketoacyl-ACP synthase	-
MZ097_RS01445 (MZ097_01445)	302008..302733	-	726	WP_248084989.1	3-ketoacyl-ACP reductase FabG2	-
MZ097_RS01450 (MZ097_01450)	302846..303379	-	534	WP_248069543.1	hotdog family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	295798..296814	1016

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-66)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11553.37 Da
• Isoelectric Point: 9.5972

>T242801 WP_014609651.1 NZ_CP096166:c299244-298945 [Shewanella sp. JNE7]
MKNKRYKLSKLAQTHLLKIKDYTIQHFSESQWHKYKESLISGLQMLADNPGLGRSCEDIYPNGFYFPIAKHTAYFTKEDD
FILIVALLGQPQLPQNHLK

Nucleotide

• Length: 300 bp

>T242801 NZ_OW967795:c602332-601868 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8920.14 Da
• Isoelectric Point: 5.0621

>AT242801 WP_011787680.1 NZ_CP096166:c299495-299253 [Shewanella sp. JNE7]
VQTLTANDAKRNFGELLLNAQREPIKISKNSKDAVVVMSIHDFEQLEAMKADYLKHCFNAAKEDLAKGNIVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT242801 NZ_OW967795:c602667-602332 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A6N3J071