Detailed information of TA system TA242799

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4622017..4623739
• Replicon: chromosome
• Accession: NZ_CP096163
• Organism: Shewanella sp. JNE10-2

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: D0FZT9
• Locus tag: MZ018_RS20485
• Protein ID: WP_000356587.1
• Coordinates: 4622017..4622955 (-)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: MZ018_RS20490
• Protein ID: WP_048608544.1
• Coordinates: 4622948..4623739 (-)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZ018_RS20465 (MZ018_20465)	4617958..4618470	-	513	WP_172689549.1	S26 family signal peptidase	-
MZ018_RS20470 (MZ018_20470)	4618454..4618801	-	348	WP_048608540.1	hypothetical protein	-
MZ018_RS20475 (MZ018_20475)	4618794..4621193	-	2400	WP_048608542.1	type IV secretion system protein TraC	-
MZ018_RS20480 (MZ018_20480)	4621193..4621885	-	693	WP_001228924.1	DsbC family protein	-
MZ018_RS20485 (MZ018_20485)	4622017..4622955	-	939	WP_000356587.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
MZ018_RS20490 (MZ018_20490)	4622948..4623739	-	792	WP_048608544.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
MZ018_RS20495 (MZ018_20495)	4623960..4624346	-	387	WP_000180225.1	TraA family conjugative transfer protein	-
MZ018_RS20500 (MZ018_20500)	4624343..4624915	-	573	WP_139175592.1	type IV conjugative transfer system lipoprotein TraV	-
MZ018_RS20505 (MZ018_20505)	4624990..4626279	-	1290	WP_085285719.1	TraB/VirB10 family protein	-
MZ018_RS20510 (MZ018_20510)	4626282..4627178	-	897	WP_048608549.1	type-F conjugative transfer system secretin TraK	-
MZ018_RS20515 (MZ018_20515)	4627162..4627788	-	627	WP_000667170.1	TraE/TraK family type IV conjugative transfer system protein	-
MZ018_RS20520 (MZ018_20520)	4627785..4628066	-	282	WP_000433889.1	type IV conjugative transfer system protein TraL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-97)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35548.82 Da
• Isoelectric Point: 4.9081

>T242799 WP_000356587.1 NZ_CP096163:c4622955-4622017 [Shewanella sp. JNE10-2]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Nucleotide

• Length: 939 bp

>T242799 NZ_OW967795:183172-183279 [Escherichia coli]
ATGACGCTCGCAGAGTTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30100.44 Da
• Isoelectric Point: 9.3513

>AT242799 WP_048608544.1 NZ_CP096163:c4623739-4622948 [Shewanella sp. JNE10-2]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPDAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

>AT242799 NZ_OW967795:c183115-183057 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A1U9VZ44