Detailed information of TA system TA242798

Bioinformatically predicted

Overview

TA module

• Type: VII
• Classification (family/domain): HepT-MntA/HepT(toxin)
• Location: 4252308..4253139
• Replicon: chromosome
• Accession: NZ_CP096163
• Organism: Shewanella sp. JNE10-2

Toxin (Protein)

• Gene name: hepT
• Uniprot ID: -
• Locus tag: MZ018_RS18785
• Protein ID: WP_088585313.1
• Coordinates: 4252723..4253139 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: mntA
• Uniprot ID: -
• Locus tag: MZ018_RS18780
• Protein ID: WP_088585314.1
• Coordinates: 4252308..4252730 (+)
• Length: 141 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZ018_RS18755 (MZ018_18755)	4248532..4248816	-	285	WP_126491562.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MZ018_RS18760 (MZ018_18760)	4248806..4249045	-	240	WP_126491561.1	CopG family ribbon-helix-helix protein	-
MZ018_RS18765 (MZ018_18765)	4249761..4250969	-	1209	WP_248084660.1	J domain-containing protein	-
MZ018_RS18770 (MZ018_18770)	4251181..4251528	-	348	WP_126491559.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MZ018_RS18775 (MZ018_18775)	4251530..4251790	-	261	WP_115017884.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MZ018_RS18780 (MZ018_18780)	4252308..4252730	+	423	WP_088585314.1	nucleotidyltransferase domain-containing protein	Antitoxin
MZ018_RS18785 (MZ018_18785)	4252723..4253139	+	417	WP_088585313.1	DUF86 domain-containing protein	Toxin
MZ018_RS18790 (MZ018_18790)	4253535..4254887	-	1353	WP_248084661.1	phosphoglucosamine mutase	-
MZ018_RS18795 (MZ018_18795)	4254962..4256902	-	1941	WP_248084662.1	nucleoside-diphosphate sugar epimerase/dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease HepT-like (12-130)

Antitoxin

• Polymerase beta, nucleotidyltransferase (9-96)

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 16056.55 Da
• Isoelectric Point: 7.3244

>T242798 WP_088585313.1 NZ_CP096163:4252723-4253139 [Shewanella sp. JNE10-2]
MNDIIINKIATIKRCIKRIQQVYGDGSMFKQDFTLQDSVILNLQRCCEASIDIANHINRQQQLGIPQSSRDSFTLLSQNK
IINQQLADNLKKMVGLRNIAVHDYQELNLDIVVHVVQHHLEDFEQFIEVIKFCPRMSY

Nucleotide

• Length: 417 bp

>T242798 NZ_OW967795:182689-182796 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 141 a.a.
• Molecular weight: 15861.89 Da
• Isoelectric Point: 5.1231

>AT242798 WP_088585314.1 NZ_CP096163:4252308-4252730 [Shewanella sp. JNE10-2]
MQQLNESIIINLLQDNIPQLRLIYLFGSYAQGTQHRNSDIDIAVLADVTLDNIARWQLAQKLASALDTDVDLVDLRTAST
VLCQQVVTQGKRLWGTRQDDEIFAVKTISMYQHLQAERQAIIDDATAKTTANDHRGRHFE

Nucleotide

• Length: 423 bp

>AT242798 NZ_OW967795:c182632-182574 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC