Detailed information of TA system TA242797

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazF-chpS/PRK09907-MazE
• Location: 4210129..4210712
• Replicon: chromosome
• Accession: NZ_CP096163
• Organism: Shewanella sp. JNE10-2

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: A0A448CPD5
• Locus tag: MZ018_RS18570
• Protein ID: WP_014610905.1
• Coordinates: 4210129..4210458 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: -
• Locus tag: MZ018_RS18575
• Protein ID: WP_086904821.1
• Coordinates: 4210458..4210712 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZ018_RS18550 (MZ018_18550)	4206763..4208013	-	1251	WP_248069812.1	type II toxin-antitoxin system HipA family toxin	-
MZ018_RS18555 (MZ018_18555)	4208010..4208315	-	306	WP_004249763.1	helix-turn-helix domain-containing protein	-
MZ018_RS18560 (MZ018_18560)	4208599..4209329	+	731	Protein_3601	IS3 family transposase	-
MZ018_RS18565 (MZ018_18565)	4209650..4209999	-	350	Protein_3602	helix-turn-helix domain-containing protein	-
MZ018_RS18570 (MZ018_18570)	4210129..4210458	-	330	WP_014610905.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MZ018_RS18575 (MZ018_18575)	4210458..4210712	-	255	WP_086904821.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
MZ018_RS18580 (MZ018_18580)	4211098..4212555	+	1458	WP_248069810.1	gamma-mobile-trio recombinase GmtY	-
MZ018_RS18585 (MZ018_18585)	4212555..4215227	+	2673	WP_119565105.1	integrase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (6-107)

Antitoxin

• SpoVT-AbrB domain (6-46)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12058.97 Da
• Isoelectric Point: 8.9492

>T242797 WP_014610905.1 NZ_CP096163:c4210458-4210129 [Shewanella sp. JNE10-2]
MSYTPKRGDIVWIDFDPSAGHEQAHHRPALVLSPEPFNKQIQLALVAPITSRVRGHGFEVAVDTDKTKGVVLCQQVKTID
YAARDVKYIEKAPVAVLNEVLAKVRVLVS

Nucleotide

• Length: 330 bp

>T242797 NZ_OW967519:67492-67974 [Klebsiella oxytoca]
GTGGGATGTATAACAGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGAGAAACGGTACTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAGGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTCTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATATCTCATTGCACGTAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGCTTCTATGTTCACCATGGATTTAAGGCATCACAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 8922.19 Da
• Isoelectric Point: 4.3021

>AT242797 WP_086904821.1 NZ_CP096163:c4210712-4210458 [Shewanella sp. JNE10-2]
MQTSIKKWGNSAGAIIPAAVLKKAGFGMGDQVEIEVVQGRIVMSPATPIFTLDELLSASPKGSFELDSEDTQWLSSSPVG
KEEI

Nucleotide

• Length: 255 bp

>AT242797 NZ_OW967519:67238-67504 [Klebsiella oxytoca]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGGGCACTCATCGATGCCGCTGCAGAAATCCTTCA
TAAATCGCGAACCGACTTCATTCTTGAGATGGCCTGCAAGGCTGCGGAGAACGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGATGTATAA

Structures

Toxin

• AlphaFold DB: A0A448CPD5