Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/- |
| Location | 4198324..4198916 | Replicon | chromosome |
| Accession | NZ_CP096163 | ||
| Organism | Shewanella sp. JNE10-2 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | MZ018_RS18500 | Protein ID | WP_248069775.1 |
| Coordinates | 4198324..4198578 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A252ENK1 |
| Locus tag | MZ018_RS18505 | Protein ID | WP_014610929.1 |
| Coordinates | 4198575..4198916 (+) | Length | 114 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MZ018_RS18465 (MZ018_18465) | 4193448..4194173 | + | 726 | WP_220777342.1 | zeta toxin family protein | - |
| MZ018_RS18470 (MZ018_18470) | 4194195..4194359 | + | 165 | WP_014610884.1 | hypothetical protein | - |
| MZ018_RS18475 (MZ018_18475) | 4194437..4194613 | - | 177 | WP_248085063.1 | tyrosine-type recombinase/integrase | - |
| MZ018_RS18480 (MZ018_18480) | 4194685..4195698 | - | 1014 | WP_248069778.1 | dTDP-glucose 4,6-dehydratase | - |
| MZ018_RS18485 (MZ018_18485) | 4196249..4196626 | - | 378 | Protein_3586 | transposase | - |
| MZ018_RS18490 (MZ018_18490) | 4196831..4197319 | + | 489 | WP_069453178.1 | mobile mystery protein A | - |
| MZ018_RS18495 (MZ018_18495) | 4197316..4197927 | + | 612 | WP_248069777.1 | mobile mystery protein B | - |
| MZ018_RS18500 (MZ018_18500) | 4198324..4198578 | + | 255 | WP_248069775.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MZ018_RS18505 (MZ018_18505) | 4198575..4198916 | + | 342 | WP_014610929.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MZ018_RS18510 (MZ018_18510) | 4199079..4199459 | - | 381 | WP_248069773.1 | helix-turn-helix transcriptional regulator | - |
| MZ018_RS18515 (MZ018_18515) | 4199456..4200823 | - | 1368 | WP_248069771.1 | HipA domain-containing protein | - |
| MZ018_RS18520 (MZ018_18520) | 4201178..4201495 | - | 318 | WP_014610892.1 | CcdB family protein | - |
| MZ018_RS18525 (MZ018_18525) | 4201495..4201740 | - | 246 | WP_014610893.1 | type II toxin-antitoxin system CcdA family antitoxin | - |
| MZ018_RS18530 (MZ018_18530) | 4202051..4202143 | + | 93 | Protein_3595 | transposase family protein | - |
| MZ018_RS18535 (MZ018_18535) | 4202981..4203247 | + | 267 | WP_140906946.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 4196249..4196698 | 449 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 9508.02 Da Isoelectric Point: 10.1453
>T242796 WP_248069775.1 NZ_CP096163:4198324-4198578 [Shewanella sp. JNE10-2]
MNKKHLRTLTAIFARPVSGAIKWSDIEALFIALGADIEEREGSRIGVVLFGEVQVYHRPHPQKETDKDAVINIKKWLERN
GVKA
MNKKHLRTLTAIFARPVSGAIKWSDIEALFIALGADIEEREGSRIGVVLFGEVQVYHRPHPQKETDKDAVINIKKWLERN
GVKA
Download Length: 255 bp
>T242796 NZ_OW967519:11347-11763 [Klebsiella oxytoca]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA
Antitoxin
Download Length: 114 a.a. Molecular weight: 12379.91 Da Isoelectric Point: 4.3992
>AT242796 WP_014610929.1 NZ_CP096163:4198575-4198916 [Shewanella sp. JNE10-2]
MKNLMMINGVKAFIDYDPDAETFRGEFVGLNGGADFYGESVAQLEAEGAKSLSVFLEMCQERGIEPYKNFSGKFNVRISP
EVHARLNEIALSQSISLNAAVENAVNDYIAHSA
MKNLMMINGVKAFIDYDPDAETFRGEFVGLNGGADFYGESVAQLEAEGAKSLSVFLEMCQERGIEPYKNFSGKFNVRISP
EVHARLNEIALSQSISLNAAVENAVNDYIAHSA
Download Length: 342 bp
>AT242796 NZ_OW967519:11120-11350 [Klebsiella oxytoca]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAAGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAAGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|