Detailed information of TA system TA242792

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1488473..1489023
• Replicon: chromosome
• Accession: NZ_CP096163
• Organism: Shewanella sp. JNE10-2

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MZ018_RS06485
• Protein ID: WP_014609651.1
• Coordinates: 1488473..1488772 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A6N3J071
• Locus tag: MZ018_RS06490
• Protein ID: WP_011787680.1
• Coordinates: 1488781..1489023 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZ018_RS06465 (MZ018_06465)	1484360..1484836	-	477	WP_248068224.1	GNAT family N-acetyltransferase	-
MZ018_RS06470 (MZ018_06470)	1485326..1486342	-	1017	WP_248085124.1	IS110-like element ISSpu22 family transposase	-
MZ018_RS06475 (MZ018_06475)	1486918..1487121	+	204	WP_061782969.1	hypothetical protein	-
MZ018_RS06480 (MZ018_06480)	1487355..1488221	+	867	WP_025008029.1	DUF6236 family protein	-
MZ018_RS06485 (MZ018_06485)	1488473..1488772	-	300	WP_014609651.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MZ018_RS06490 (MZ018_06490)	1488781..1489023	-	243	WP_011787680.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MZ018_RS06495 (MZ018_06495)	1489501..1490244	-	744	WP_248069536.1	hypothetical protein	-
MZ018_RS06500 (MZ018_06500)	1490276..1491535	-	1260	WP_248069538.1	beta-ketoacyl-ACP synthase	-
MZ018_RS06505 (MZ018_06505)	1491536..1492261	-	726	WP_248084989.1	3-ketoacyl-ACP reductase FabG2	-
MZ018_RS06510 (MZ018_06510)	1492374..1492907	-	534	WP_248069543.1	hotdog family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1485326..1486342	1016

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-66)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11553.37 Da
• Isoelectric Point: 9.5972

>T242792 WP_014609651.1 NZ_CP096163:c1488772-1488473 [Shewanella sp. JNE10-2]
MKNKRYKLSKLAQTHLLKIKDYTIQHFSESQWHKYKESLISGLQMLADNPGLGRSCEDIYPNGFYFPIAKHTAYFTKEDD
FILIVALLGQPQLPQNHLK

Nucleotide

• Length: 300 bp

>T242792 NZ_OW967518:c1352997-1352623 [Klebsiella oxytoca]
ATGCAAATACAATCCCTGCCCCCTCAAAGGGCGGCATCGTCACGTCTGTCATCAGTCAAAATCTGGCAAAAATTACTGGA
GTATCTGCTGGAGCAACACTACGGCCTTACCCTCAACGACACACCGTTTGGCAACGACAGTGTGATCCAGAAACACATTG
ATGCGGGAATCTCACTGTGTGACGCTGTAAATTTTATCGTGGAAAAGTACGACCTGGTGCGTACTGACCGTCACGGCTTC
AGCGTGAAAGAGCAGTCTCCGTTTATCGGCAGCCTTGATATGCTTCGAGCCCGGAAGGCTACCGGGCTGATGACCCGCAA
GGGATATAAAACCGTTACTGACATCACAGGTGGCAGATTCAGCGGAGGGAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8920.14 Da
• Isoelectric Point: 5.0621

>AT242792 WP_011787680.1 NZ_CP096163:c1489023-1488781 [Shewanella sp. JNE10-2]
VQTLTANDAKRNFGELLLNAQREPIKISKNSKDAVVVMSIHDFEQLEAMKADYLKHCFNAAKEDLAKGNIVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT242792 NZ_OW967518:c1353395-1353036 [Klebsiella oxytoca]
ATGCAGAAAGCAACCCGTGTAATCAACCATAACATCACTGAACCCTGGTGGGGCCTCAGACGCAACATCACGCCGTGTTT
TGGTGCTCGGCTGGTACAGGAGGGTAACCACCTGCATTACCTTGCTGACCGCGCCAGCATTGCCGGGACATTTAATGACG
CAGATTTACGCCATCTGGACCAGGCATTTCCGGTACTGATGAAGCAGATGGAGCTTATGCTGACCAGCAATGAACTCACG
CCCCACATTCAGCGCTGCATCACGATCCACGCAAAAGGGCTGATATGTGAGGCCGATACGCTCGGTTCCTGTGGCTATTT
GTATATCGTAATTTATCCGGCGTCTGCAACAACCGCATAA

Structures

Antitoxin

• AlphaFold DB: A0A6N3J071