Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 2334692..2335053 Replicon chromosome
Accession NZ_CP096143
Organism Xanthomonas prunicola strain CIX97

Toxin (Protein)


Gene name EcnB Uniprot ID A0A836P2V1
Locus tag M0D46_RS10000 Protein ID WP_010374872.1
Coordinates 2334919..2335053 (+) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID A0A836P2N2
Locus tag M0D46_RS09995 Protein ID WP_010374875.1
Coordinates 2334692..2334844 (+) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0D46_RS09965 (M0D46_09955) 2329779..2330462 - 684 WP_252161740.1 dTMP kinase -
M0D46_RS09970 (M0D46_09960) 2330909..2331451 - 543 WP_260815385.1 GTPase -
M0D46_RS09975 (M0D46_09965) 2331448..2332365 - 918 WP_260815386.1 hypothetical protein -
M0D46_RS09980 (M0D46_09970) 2332463..2332822 - 360 WP_252161743.1 roadblock/LC7 domain-containing protein -
M0D46_RS09985 (M0D46_09975) 2332886..2333338 - 453 WP_260815387.1 roadblock/LC7 domain-containing protein -
M0D46_RS09990 (M0D46_09980) 2333661..2334584 + 924 WP_260815388.1 arginase -
M0D46_RS09995 (M0D46_09985) 2334692..2334844 + 153 WP_010374875.1 entericidin A/B family lipoprotein Antitoxin
M0D46_RS10000 (M0D46_09990) 2334919..2335053 + 135 WP_010374872.1 entericidin A/B family lipoprotein Toxin
M0D46_RS10005 (M0D46_09995) 2335295..2335504 + 210 WP_017117799.1 CsbD family protein -
M0D46_RS10010 (M0D46_10000) 2335671..2336960 + 1290 WP_260815389.1 tryptophan--tRNA ligase -
M0D46_RS10015 (M0D46_10005) 2337092..2338036 + 945 WP_260815390.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4475.37 Da        Isoelectric Point: 10.2040

>T242788 WP_010374872.1 NZ_CP096143:2334919-2335053 [Xanthomonas prunicola]
MKRAIVLLVLSMLSVGMLSGCNTVAGAGKDVKGAGEKVEDAARK

Download         Length: 135 bp

>T242788 NZ_OW967388:c2787639-2787536 [Enterobacter cloacae]
GGCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5065.02 Da        Isoelectric Point: 8.7942

>AT242788 WP_010374875.1 NZ_CP096143:2334692-2334844 [Xanthomonas prunicola]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGGKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT242788 NZ_OW967388:2787533-2787732 [Enterobacter cloacae]
GATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGG
CATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTGGTCT
GAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836P2V1

Antitoxin

Source ID Structure
AlphaFold DB A0A836P2N2

References