Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) EcnAB/-
Location 3085403..3085764 Replicon chromosome
Accession NZ_CP096142
Organism Xanthomonas prunicola strain CIX249

Toxin (Protein)


Gene name EcnB Uniprot ID A0A836P2V1
Locus tag M0D43_RS13095 Protein ID WP_010374872.1
Coordinates 3085630..3085764 (+) Length 45 a.a.

Antitoxin (Protein)


Gene name EcnA Uniprot ID A0A836P2N2
Locus tag M0D43_RS13090 Protein ID WP_010374875.1
Coordinates 3085403..3085555 (+) Length 51 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0D43_RS13060 (M0D43_13035) 3080492..3081175 - 684 WP_252161740.1 dTMP kinase -
M0D43_RS13065 (M0D43_13040) 3081622..3082164 - 543 WP_252161741.1 GTPase -
M0D43_RS13070 (M0D43_13045) 3082161..3083078 - 918 WP_252161742.1 hypothetical protein -
M0D43_RS13075 (M0D43_13050) 3083176..3083535 - 360 WP_252161743.1 roadblock/LC7 domain-containing protein -
M0D43_RS13080 (M0D43_13055) 3083599..3084051 - 453 WP_252161744.1 roadblock/LC7 domain-containing protein -
M0D43_RS13085 (M0D43_13060) 3084372..3085295 + 924 WP_252161745.1 arginase -
M0D43_RS13090 (M0D43_13065) 3085403..3085555 + 153 WP_010374875.1 entericidin A/B family lipoprotein Antitoxin
M0D43_RS13095 (M0D43_13070) 3085630..3085764 + 135 WP_010374872.1 entericidin A/B family lipoprotein Toxin
M0D43_RS13100 (M0D43_13075) 3086004..3086213 + 210 WP_017117799.1 CsbD family protein -
M0D43_RS13105 (M0D43_13080) 3086380..3087669 + 1290 WP_252161746.1 tryptophan--tRNA ligase -
M0D43_RS13110 (M0D43_13085) 3087740..3088745 + 1006 Protein_2548 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Entericidin A/B

(23-42)

Antitoxin

Entericidin A/B

(23-42)


Sequences

Toxin        


Download         Length: 45 a.a.        Molecular weight: 4475.37 Da        Isoelectric Point: 10.2040

>T242787 WP_010374872.1 NZ_CP096142:3085630-3085764 [Xanthomonas prunicola]
MKRAIVLLVLSMLSVGMLSGCNTVAGAGKDVKGAGEKVEDAARK

Download         Length: 135 bp

>T242787 NZ_OW967388:c2306331-2305846 [Enterobacter cloacae]
GTGGGACGTGTAACAGCACCAGAGCCCTTATCCAGCGTCCATCAACTGGCGGAGTTCGTCAGCGGAGAGGCCGTGCTTGA
CGAATGGCTAAAACAAAGAGGTCTGAAAAACCAGGCGCTCGGCGCAGCCCGAACCTTTGTCGTTTGTAAAACGGGCACGA
AGCAGGTCGCGGGATTTTACTCTCTGGCTACCGGCAGCGTTAACCATACGCAAGCGACAGGGAATCTGCGGCGTAACATG
CCGGATCCCATTCCCGTGATTATTCTTGCCCGTCTGGCAGTTGATGTCTCGTTACGCGGAAACGGGTTGGGAGCCGATTT
ACTCCACGATGCGGTTTTACGCTGTTATCGGGTAGCTGAGAATATCGGGGTGCGGGCGATTATGGTTCATGCACTCACTG
AGGAAGCCAAAGCGTTTTATATCCACCATGGTTTTAAAGCATCGCAGACTCAGGAACGGACACTGTTTCTCAGGCTTCCT
CAGTAG

Antitoxin


Download         Length: 51 a.a.        Molecular weight: 5065.02 Da        Isoelectric Point: 8.7942

>AT242787 WP_010374875.1 NZ_CP096142:3085403-3085555 [Xanthomonas prunicola]
MKRLLTLMVLGLFSAGVMTGCNTVAGAGKDMQGAGGKVEKTAEKCSDGKC

Download         Length: 153 bp

>AT242787 NZ_OW967388:c2306585-2306319 [Enterobacter cloacae]
ATGAAATCAGATGTTCAACTCAATCTCAGAGCCAAAGAATCCCAGCGGGCGCTTATCGATGCCGCCGCAGAGATCCTCCA
TAAATCACGCACGGACTTCATTCTGGAGATGGCCTGTCAGGCAGCCGAGAATGTGATCCTCGATCGACGTGTATTCAATT
TTAACGATGAACAGTACGCAGAGTTCATTGACATGCTCGATGCCCCGGTCGCGGACGATCCGGCCATAGAAAAACTGCTG
GCAAGGAAACCACAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836P2V1

Antitoxin

Source ID Structure
AlphaFold DB A0A836P2N2

References