Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 22963..23491 | Replicon | plasmid pJNE5-64k |
| Accession | NZ_CP096122 | ||
| Organism | Acinetobacter portensis strain JNE5 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | MZO21_RS14555 | Protein ID | WP_248103949.1 |
| Coordinates | 22963..23256 (-) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | N9B5Q7 |
| Locus tag | MZO21_RS14560 | Protein ID | WP_000246756.1 |
| Coordinates | 23246..23491 (-) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MZO21_RS14520 (MZO21_14515) | 18156..18284 | - | 129 | Protein_18 | IS3 family transposase | - |
| MZO21_RS14525 (MZO21_14520) | 18405..18707 | - | 303 | WP_092818272.1 | XRE family transcriptional regulator | - |
| MZO21_RS14530 (MZO21_14525) | 18700..19056 | - | 357 | WP_092818271.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MZO21_RS14535 (MZO21_14530) | 19638..20528 | - | 891 | WP_248103956.1 | LysR family transcriptional regulator | - |
| MZO21_RS14540 (MZO21_14535) | 20678..21271 | + | 594 | WP_248103953.1 | NAD(P)H-dependent oxidoreductase | - |
| MZO21_RS14545 (MZO21_14540) | 21281..21595 | + | 315 | WP_248103960.1 | putative quinol monooxygenase | - |
| MZO21_RS14550 (MZO21_14545) | 21775..22926 | + | 1152 | WP_248104258.1 | IS4 family transposase | - |
| MZO21_RS14555 (MZO21_14550) | 22963..23256 | - | 294 | WP_248103949.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MZO21_RS14560 (MZO21_14555) | 23246..23491 | - | 246 | WP_000246756.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| MZO21_RS14565 (MZO21_14560) | 23604..24545 | - | 942 | WP_154773788.1 | lipid A biosynthesis acyltransferase | - |
| MZO21_RS14570 (MZO21_14565) | 24702..24992 | - | 291 | WP_154773789.1 | type II toxin-antitoxin system YafQ family toxin | - |
| MZO21_RS14575 (MZO21_14570) | 24979..25239 | - | 261 | WP_005265047.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| MZO21_RS14580 (MZO21_14575) | 25378..26109 | - | 732 | WP_104500406.1 | GntR family transcriptional regulator | - |
| MZO21_RS14585 (MZO21_14580) | 26213..27502 | + | 1290 | WP_104500405.1 | SLC13 family permease | - |
| MZO21_RS14590 (MZO21_14585) | 27510..28313 | + | 804 | WP_104489951.1 | amidohydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..64629 | 64629 | |
| - | inside | IScluster/Tn | - | - | 28460..64046 | 35586 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11391.66 Da Isoelectric Point: 10.5710
>T242777 WP_248103949.1 NZ_CP096122:c23256-22963 [Acinetobacter portensis]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVR
KRADSIVYDEAKKRIKD
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVR
KRADSIVYDEAKKRIKD
Download Length: 294 bp
>T242777 NZ_OW967374:4527835-4528053 [Klebsiella oxytoca]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGCTTACGACGTTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCTGATAATGAACTGGCGGTATTTTACTCAGCAGCCGATCATCGTCTTGCTGAAC
TGACGATGAATAAACTGTATGACAAGATCCCGCCATCGGTCTGGAAATTCATCCGCTAA
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGCTTACGACGTTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCTGATAATGAACTGGCGGTATTTTACTCAGCAGCCGATCATCGTCTTGCTGAAC
TGACGATGAATAAACTGTATGACAAGATCCCGCCATCGGTCTGGAAATTCATCCGCTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9235.61 Da Isoelectric Point: 4.3142
>AT242777 WP_000246756.1 NZ_CP096122:c23491-23246 [Acinetobacter portensis]
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L
MATVNFRVDEALKEKSYSILKEQGIAPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L
Download Length: 246 bp
>AT242777 NZ_OW967374:4527434-4527808 [Klebsiella oxytoca]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTTAATGACCCAACCTCTGCTGTCAATCTTCAGCTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGGTGACTCAGCTTGACGAATATCTG
GATGACACTTTCGTGTTGTTCAGCAACTACGGCATTAACACTGCAGATCTGCAGAAATGGCGTAAATCAGGCAACAGGTT
ATTCCGCTGCTTTGTGAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAA
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTTAATGACCCAACCTCTGCTGTCAATCTTCAGCTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGGTGACTCAGCTTGACGAATATCTG
GATGACACTTTCGTGTTGTTCAGCAACTACGGCATTAACACTGCAGATCTGCAGAAATGGCGTAAATCAGGCAACAGGTT
ATTCCGCTGCTTTGTGAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|