Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 202523..204146 Replicon plasmid p22-1
Accession NZ_CP096119
Organism Salmonella enterica subsp. enterica serovar Indiana strain 22

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag MZK41_RS24880 Protein ID WP_000088046.1
Coordinates 202821..204146 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag MZK41_RS24875 Protein ID WP_024136327.1
Coordinates 202523..202816 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZK41_RS24850 (MZK41_24850) 198367..199608 + 1242 WP_001053338.1 VWA domain-containing protein -
MZK41_RS25115 199699..199830 + 132 WP_000374059.1 hypothetical protein -
MZK41_RS24855 (MZK41_24855) 200171..200452 - 282 WP_000077926.1 hypothetical protein -
MZK41_RS24860 (MZK41_24860) 200502..200693 - 192 WP_000398480.1 hypothetical protein -
MZK41_RS24865 (MZK41_24865) 200785..201126 - 342 WP_001151575.1 hypothetical protein -
MZK41_RS24870 (MZK41_24870) 201499..201891 + 393 WP_000341066.1 hypothetical protein -
MZK41_RS24875 (MZK41_24875) 202523..202816 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
MZK41_RS24880 (MZK41_24880) 202821..204146 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
MZK41_RS24885 (MZK41_24885) 204207..204413 + 207 WP_000134171.1 hypothetical protein -
MZK41_RS24890 (MZK41_24890) 204515..204925 + 411 WP_000985911.1 hypothetical protein -
MZK41_RS24895 (MZK41_24895) 204938..205753 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
MZK41_RS24900 (MZK41_24900) 206007..206432 + 426 WP_001043843.1 hypothetical protein -
MZK41_RS24905 (MZK41_24905) 206721..208079 - 1359 Protein_213 Tn3-like element TnAs1 family transposase -
MZK41_RS24910 (MZK41_24910) 208147..208851 + 705 WP_001067858.1 IS6-like element IS26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / aac(3)-IVa / aph(4)-Ia / sul2 / floR / aph(3'')-Ib / aph(6)-Id / tet(A) / blaCTX-M-65 - 1..235522 235522


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T242768 WP_000088046.1 NZ_CP096119:202821-204146 [Salmonella enterica subsp. enterica serovar Indiana]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T242768 NZ_OW967263:c4889884-4889510 [Citrobacter freundii]
ATGGTCAAAGGATCCGCGCTTTTTGATACCAACATCCTCATCGATCTGTTTAGTGGGAGAAATGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAATGCAATCAGCCTCATTACATGGATGGAGGTGATGGTGGGTGCAAAAAAATACCATCAGG
AAGCCCGTACTCGTGTTGCGCTAGGTGCTTTTAACGTGATCGGCGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGACAGGAATATGGGATGAAATTGCCGGATGCCATTATTTTGGCAACAGCACAGATTCATCGTCTTACGCTGGTTACGCG
AAATACTAAGGATTTTGCAGGCCTATCCGGTGTGGTCACACCGTATACATTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT242768 WP_024136327.1 NZ_CP096119:202523-202816 [Salmonella enterica subsp. enterica serovar Indiana]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT242768 NZ_OW967263:c4890126-4889884 [Citrobacter freundii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGAAGTGATTAAACGTCTTGATGATCTCAAGGT
GCAGCGCAACCTGCCGCGAGCAGAACTTTTACGGGAGGCCGTTGAACAGTATCTTGAGAGACAGGATCAGGCTGAAACCA
CAATTTCACGTGCTCTTGGGCTGTGGCAAGGCTGTGAGGAAGATGGTGTTGAATACCAGCGTAAACTCCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References