Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4280293..4280809 Replicon chromosome
Accession NZ_CP096118
Organism Salmonella enterica subsp. enterica serovar Indiana strain 22

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag MZK41_RS20975 Protein ID WP_000220577.1
Coordinates 4280293..4280577 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag MZK41_RS20980 Protein ID WP_000212724.1
Coordinates 4280567..4280809 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZK41_RS20960 (4275409) 4275409..4277061 + 1653 WP_000155050.1 alpha,alpha-phosphotrehalase -
MZK41_RS20965 (4277470) 4277470..4279608 + 2139 WP_023226981.1 anaerobic ribonucleoside-triphosphate reductase -
MZK41_RS20970 (4279825) 4279825..4280289 + 465 WP_001009173.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MZK41_RS20975 (4280293) 4280293..4280577 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MZK41_RS20980 (4280567) 4280567..4280809 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MZK41_RS20985 (4280887) 4280887..4282800 - 1914 WP_023226980.1 BglG family transcription antiterminator -
MZK41_RS20990 (4282817) 4282817..4283557 - 741 WP_000779254.1 KDGP aldolase family protein -
MZK41_RS20995 (4283554) 4283554..4284672 - 1119 WP_023137277.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MZK41_RS21000 (4284656) 4284656..4285789 - 1134 WP_023226979.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T242765 WP_000220577.1 NZ_CP096118:c4280577-4280293 [Salmonella enterica subsp. enterica serovar Indiana]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T242765 NZ_OW967263:4027791-4028132 [Citrobacter freundii]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATAGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGTAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT242765 WP_000212724.1 NZ_CP096118:c4280809-4280567 [Salmonella enterica subsp. enterica serovar Indiana]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT242765 NZ_OW967263:4027453-4027770 [Citrobacter freundii]
ATGAGCAAAATCACATGGGGTCTGCAGCGTGATATCACGCCACGTCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATGACCGGCAAGTTCAGTGACATCGAATACCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACTGGTGAACTCAGCACCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References