Detailed information of TA system TA242761

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3548449..3549069
• Replicon: chromosome
• Accession: NZ_CP096118
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain 22

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: MZK41_RS17490
• Protein ID: WP_001280991.1
• Coordinates: 3548851..3549069 (+)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: MZK41_RS17485
• Protein ID: WP_000344807.1
• Coordinates: 3548449..3548823 (+)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZK41_RS17475 (3543588)	3543588..3544781	+	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-
MZK41_RS17480 (3544804)	3544804..3547953	+	3150	WP_051129102.1	efflux RND transporter permease AcrB	-
MZK41_RS17485 (3548449)	3548449..3548823	+	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
MZK41_RS17490 (3548851)	3548851..3549069	+	219	WP_001280991.1	HHA domain-containing protein	Toxin
MZK41_RS17495 (3549248)	3549248..3549799	+	552	WP_001278793.1	maltose O-acetyltransferase	-
MZK41_RS17500 (3549917)	3549917..3550387	+	471	WP_000136181.1	YlaC family protein	-
MZK41_RS17505 (3550443)	3550443..3550583	-	141	WP_001197749.1	type B 50S ribosomal protein L36	-
MZK41_RS17510 (3550589)	3550589..3550849	-	261	WP_000801415.1	type B 50S ribosomal protein L31	-
MZK41_RS17515 (3551074)	3551074..3552624	+	1551	WP_023210786.1	EAL domain-containing protein	-
MZK41_RS17525 (3552855)	3552855..3553244	+	390	WP_000961285.1	MGMT family protein	-
MZK41_RS17530 (3553277)	3553277..3553846	-	570	WP_000779802.1	YbaY family lipoprotein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T242761 WP_001280991.1 NZ_CP096118:3548851-3549069 [Salmonella enterica subsp. enterica serovar Indiana]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T242761 NZ_OW967263:c366597-366280 [Citrobacter freundii]
ATGTTCACATTTATTGAGCTACAAGGATTTAGTAAACGCCGTCCGTTACTTTTGCCTGACGATGAGTTTCGCGCTTTTCA
AGAGGCGCTTATAGAGAACCCTGAGGCTGGAGATACTATCGCTGGTACAGGTGGATTCAGAAAAATTCGCTGGAGTCGCT
CTGGTATGGGCAAACGCAGCGGTATTAGGGTTATCTATTACAACGTGACGCGCAAAGGTCGAATCTATCTCGCTTTGCTC
TATCCTAAAAATGAACAGGATGATTTAACCGAAGAGCAAAAAAGAGTTTTAATGCACTTATCCAATATGCTGATTTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT242761 WP_000344807.1 NZ_CP096118:3548449-3548823 [Salmonella enterica subsp. enterica serovar Indiana]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT242761 NZ_OW967263:c366227-365931 [Citrobacter freundii]
ATGAAAGACGAATTATTTGCCGATTTGCTGGCCAGTGCAGAAGAAATGGTGCGTATAGAGAAAGGTGAAGAAACACCTAA
GCCTGAACATGTACATACCTTTAGCGAAATTGATGTTAAAGCCATCCGCGAAGCAACAGGGTTACGCCAACAGGATTTTG
CCATAGCTGTTGGCGTGAGTTATGACCTGGTTAAAAGCTGGGAAACGAAACGACGCCAGCCGACTGGTGCACCAAGAAAA
CTGCTTTTATTAATTCAAAAAAATCCATTTATAATTAATCAATTAAAAGCAATTTAA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0