Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3548449..3549069 Replicon chromosome
Accession NZ_CP096118
Organism Salmonella enterica subsp. enterica serovar Indiana strain 22

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MZK41_RS17490 Protein ID WP_001280991.1
Coordinates 3548851..3549069 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MZK41_RS17485 Protein ID WP_000344807.1
Coordinates 3548449..3548823 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZK41_RS17475 (3543588) 3543588..3544781 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MZK41_RS17480 (3544804) 3544804..3547953 + 3150 WP_051129102.1 efflux RND transporter permease AcrB -
MZK41_RS17485 (3548449) 3548449..3548823 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MZK41_RS17490 (3548851) 3548851..3549069 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MZK41_RS17495 (3549248) 3549248..3549799 + 552 WP_001278793.1 maltose O-acetyltransferase -
MZK41_RS17500 (3549917) 3549917..3550387 + 471 WP_000136181.1 YlaC family protein -
MZK41_RS17505 (3550443) 3550443..3550583 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MZK41_RS17510 (3550589) 3550589..3550849 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MZK41_RS17515 (3551074) 3551074..3552624 + 1551 WP_023210786.1 EAL domain-containing protein -
MZK41_RS17525 (3552855) 3552855..3553244 + 390 WP_000961285.1 MGMT family protein -
MZK41_RS17530 (3553277) 3553277..3553846 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T242761 WP_001280991.1 NZ_CP096118:3548851-3549069 [Salmonella enterica subsp. enterica serovar Indiana]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T242761 NZ_OW967263:c366597-366280 [Citrobacter freundii]
ATGTTCACATTTATTGAGCTACAAGGATTTAGTAAACGCCGTCCGTTACTTTTGCCTGACGATGAGTTTCGCGCTTTTCA
AGAGGCGCTTATAGAGAACCCTGAGGCTGGAGATACTATCGCTGGTACAGGTGGATTCAGAAAAATTCGCTGGAGTCGCT
CTGGTATGGGCAAACGCAGCGGTATTAGGGTTATCTATTACAACGTGACGCGCAAAGGTCGAATCTATCTCGCTTTGCTC
TATCCTAAAAATGAACAGGATGATTTAACCGAAGAGCAAAAAAGAGTTTTAATGCACTTATCCAATATGCTGATTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT242761 WP_000344807.1 NZ_CP096118:3548449-3548823 [Salmonella enterica subsp. enterica serovar Indiana]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT242761 NZ_OW967263:c366227-365931 [Citrobacter freundii]
ATGAAAGACGAATTATTTGCCGATTTGCTGGCCAGTGCAGAAGAAATGGTGCGTATAGAGAAAGGTGAAGAAACACCTAA
GCCTGAACATGTACATACCTTTAGCGAAATTGATGTTAAAGCCATCCGCGAAGCAACAGGGTTACGCCAACAGGATTTTG
CCATAGCTGTTGGCGTGAGTTATGACCTGGTTAAAAGCTGGGAAACGAAACGACGCCAGCCGACTGGTGCACCAAGAAAA
CTGCTTTTATTAATTCAAAAAAATCCATTTATAATTAATCAATTAAAAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References