Detailed information of TA system TA242760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2568835..2569357
• Replicon: chromosome
• Accession: NZ_CP096118
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain 22

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: B5F5Y5
• Locus tag: MZK41_RS12620
• Protein ID: WP_000221343.1
• Coordinates: 2569073..2569357 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: MZK41_RS12615
• Protein ID: WP_000885424.1
• Coordinates: 2568835..2569083 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZK41_RS12595 (2564477)	2564477..2565943	+	1467	WP_023893409.1	hypothetical protein	-
MZK41_RS25095 (2565974)	2565974..2566096	-	123	WP_254891910.1	hypothetical protein	-
MZK41_RS12600 (2566560)	2566560..2566847	+	288	WP_071787797.1	helix-turn-helix domain-containing protein	-
MZK41_RS12605 (2566919)	2566919..2567827	-	909	WP_077910000.1	hypothetical protein	-
MZK41_RS12610 (2567978)	2567978..2568310	-	333	WP_023227504.1	DUF1493 family protein	-
MZK41_RS12615 (2568835)	2568835..2569083	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MZK41_RS12620 (2569073)	2569073..2569357	+	285	WP_000221343.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MZK41_RS12625 (2569405)	2569405..2569605	+	201	Protein_2477	Rid family hydrolase	-
MZK41_RS12630 (2569657)	2569657..2570736	-	1080	WP_023227502.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
MZK41_RS12635 (2570929)	2570929..2571417	-	489	WP_023227501.1	MarR family winged helix-turn-helix transcriptional regulator	-
MZK41_RS12640 (2571462)	2571462..2572970	+	1509	WP_023227500.1	FAD-dependent oxidoreductase	-
MZK41_RS12645 (2572960)	2572960..2574201	+	1242	WP_023227499.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2565992..2575827	9835

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11075.85 Da
• Isoelectric Point: 10.6500

>T242760 WP_000221343.1 NZ_CP096118:2569073-2569357 [Salmonella enterica subsp. enterica serovar Indiana]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Nucleotide

• Length: 285 bp

>T242760 NZ_OW967263:284447-284722 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT242760 WP_000885424.1 NZ_CP096118:2568835-2569083 [Salmonella enterica subsp. enterica serovar Indiana]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT242760 NZ_OW967263:284719-285078 [Citrobacter freundii]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTAATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG

Structures

Toxin

• AlphaFold DB: A0A5H5JSW4

Antitoxin

• AlphaFold DB: A0A5I0WPN5