242750

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 969899..970524 Replicon chromosome
Accession NZ_CP096118
Organism Salmonella enterica subsp. enterica serovar Indiana strain 22

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MZK41_RS04850 Protein ID WP_000911337.1
Coordinates 970126..970524 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag MZK41_RS04845 Protein ID WP_000557545.1
Coordinates 969899..970126 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZK41_RS04815 (964944) 964944..966461 + 1518 WP_000003339.1 lysine--tRNA ligase -
MZK41_RS04820 (966537) 966537..967082 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
MZK41_RS04825 (967347) 967347..968105 + 759 WP_000244318.1 amidase activator ActS -
MZK41_RS04835 (968390) 968390..969196 - 807 WP_010989071.1 DUF1460 domain-containing protein -
MZK41_RS04840 (969471) 969471..969731 - 261 WP_023227725.1 hypothetical protein -
MZK41_RS04845 (969899) 969899..970126 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
MZK41_RS04850 (970126) 970126..970524 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
MZK41_RS04855 (971328) 971328..971864 + 537 WP_023227726.1 STM3031 family outer membrane protein -
MZK41_RS04860 (971911) 971911..972543 + 633 WP_023227727.1 YfdX family protein -
MZK41_RS04865 (973262) 973262..973849 + 588 WP_023227728.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 968390..979717 11327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T242750 WP_000911337.1 NZ_CP096118:970126-970524 [Salmonella enterica subsp. enterica serovar Indiana]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

>T242750 NZ_OW967178:2807499-2807606 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT242750 WP_000557545.1 NZ_CP096118:969899-970126 [Salmonella enterica subsp. enterica serovar Indiana]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp

>AT242750 NZ_OW967178:c2807446-2807385 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References