Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 841583..842381 | Replicon | chromosome |
| Accession | NZ_CP096118 | ||
| Organism | Salmonella enterica subsp. enterica serovar Indiana strain 22 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | U9XMP3 |
| Locus tag | MZK41_RS04200 | Protein ID | WP_000854735.1 |
| Coordinates | 841583..841960 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A067H947 |
| Locus tag | MZK41_RS04205 | Protein ID | WP_001285415.1 |
| Coordinates | 842007..842381 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MZK41_RS04160 (836839) | 836839..837321 | - | 483 | Protein_817 | NAD(P)H-dependent oxidoreductase | - |
| MZK41_RS04165 (837563) | 837563..838477 | + | 915 | WP_001582341.1 | LysR family transcriptional regulator | - |
| MZK41_RS04170 (838693) | 838693..838854 | - | 162 | Protein_819 | Arm DNA-binding domain-containing protein | - |
| MZK41_RS04175 (839280) | 839280..839606 | - | 327 | WP_000779483.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MZK41_RS04180 (839603) | 839603..839866 | - | 264 | WP_001143297.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| MZK41_RS04185 (839938) | 839938..840804 | - | 867 | WP_001280433.1 | DUF4942 domain-containing protein | - |
| MZK41_RS04190 (840889) | 840889..841086 | - | 198 | WP_000839291.1 | DUF957 domain-containing protein | - |
| MZK41_RS04195 (841098) | 841098..841586 | - | 489 | WP_149442416.1 | DUF5983 family protein | - |
| MZK41_RS04200 (841583) | 841583..841960 | - | 378 | WP_000854735.1 | TA system toxin CbtA family protein | Toxin |
| MZK41_RS04205 (842007) | 842007..842381 | - | 375 | WP_001285415.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| MZK41_RS04210 (842461) | 842461..842682 | - | 222 | WP_000692309.1 | DUF987 domain-containing protein | - |
| MZK41_RS04215 (842745) | 842745..843221 | - | 477 | WP_001366855.1 | RadC family protein | - |
| MZK41_RS04220 (843237) | 843237..843716 | - | 480 | WP_000844100.1 | antirestriction protein | - |
| MZK41_RS04225 (843798) | 843798..844616 | - | 819 | WP_001175148.1 | DUF932 domain-containing protein | - |
| MZK41_RS04230 (844706) | 844706..844939 | - | 234 | WP_001278287.1 | DUF905 family protein | - |
| MZK41_RS04235 (844945) | 844945..845622 | - | 678 | WP_001097302.1 | hypothetical protein | - |
| MZK41_RS04240 (845770) | 845770..846450 | - | 681 | WP_001282919.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 834230..894986 | 60756 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14061.07 Da Isoelectric Point: 8.2904
>T242748 WP_000854735.1 NZ_CP096118:c841960-841583 [Salmonella enterica subsp. enterica serovar Indiana]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T242748 NZ_OW967178:2473797-2473973 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTGAGTTAA
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTGAGTTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13663.32 Da Isoelectric Point: 5.8640
>AT242748 WP_001285415.1 NZ_CP096118:c842381-842007 [Salmonella enterica subsp. enterica serovar Indiana]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS
Download Length: 375 bp
>AT242748 NZ_OW967178:2474019-2474435 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACAGTTGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAATTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | U9XMP3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A067H947 |