Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2142038..2142552 Replicon chromosome
Accession NZ_CP096114
Organism Staphylococcus argenteus strain MRSA-139-14-168

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7JQI0
Locus tag M0D62_RS10455 Protein ID WP_000233591.1
Coordinates 2142038..2142247 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag M0D62_RS10460 Protein ID WP_000138934.1
Coordinates 2142259..2142552 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0D62_RS10435 (M0D62_10425) 2137381..2138745 - 1365 WP_047437297.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
M0D62_RS10440 (M0D62_10430) 2138760..2139830 - 1071 WP_047437294.1 D-alanine--D-alanine ligase -
M0D62_RS10445 (M0D62_10435) 2140149..2141351 + 1203 WP_001109945.1 FtsW/RodA/SpoVE family cell cycle protein -
M0D62_RS10450 (M0D62_10440) 2141772..2141909 - 138 WP_000828355.1 Lmo0850 family protein -
M0D62_RS10455 (M0D62_10445) 2142038..2142247 - 210 WP_000233591.1 heavy metal-associated domain-containing protein Toxin
M0D62_RS10460 (M0D62_10450) 2142259..2142552 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
M0D62_RS10465 (M0D62_10455) 2142720..2144204 + 1485 WP_047437291.1 cardiolipin synthase -
M0D62_RS10470 (M0D62_10460) 2144233..2144880 + 648 WP_047437288.1 HD domain-containing protein -
M0D62_RS10475 (M0D62_10465) 2145609..2146478 - 870 WP_000725805.1 membrane protein insertase YidC -
M0D62_RS10480 (M0D62_10470) 2146564..2147205 - 642 WP_047437285.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7827.81 Da        Isoelectric Point: 4.2681

>T242743 WP_000233591.1 NZ_CP096114:c2142247-2142038 [Staphylococcus argenteus]
MVHQNTIYTAGIETEEQVNQLTERISNMIGVHKVNINIIDGEVVVAYETPANLNSIEKEIYDTGYKIVY

Download         Length: 210 bp

>T242743 NZ_OW967178:905498-905905 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCGCAGTGGCTTTCCTTGCTGATCCACGGGTTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT242743 WP_000138934.1 NZ_CP096114:c2142552-2142259 [Staphylococcus argenteus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT242743 NZ_OW967178:905251-905517 [Escherichia coli]
ATGGATATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGTGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7JQI0

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References