Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1925496..1926283 Replicon chromosome
Accession NZ_CP096114
Organism Staphylococcus argenteus strain MRSA-139-14-168

Toxin (Protein)


Gene name tsbT Uniprot ID A0A7U7PZK3
Locus tag M0D62_RS09190 Protein ID WP_000031103.1
Coordinates 1925496..1925651 (-) Length 52 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A7U7JVF2
Locus tag M0D62_RS09195 Protein ID WP_047430475.1
Coordinates 1925684..1926283 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0D62_RS09170 (M0D62_09160) 1920687..1921799 - 1113 WP_031787927.1 GAF domain-containing sensor histidine kinase -
M0D62_RS09175 (M0D62_09165) 1921961..1922782 + 822 WP_088811277.1 RluA family pseudouridine synthase -
M0D62_RS09180 (M0D62_09170) 1923074..1924459 - 1386 WP_047437339.1 class II fumarate hydratase -
M0D62_RS09185 (M0D62_09175) 1924630..1925031 - 402 WP_047437336.1 hypothetical protein -
M0D62_RS09190 (M0D62_09180) 1925496..1925651 - 156 WP_000031103.1 SAS053 family protein Toxin
M0D62_RS09195 (M0D62_09185) 1925684..1926283 - 600 WP_047430475.1 glucosamine-6-phosphate isomerase Antitoxin
M0D62_RS09200 (M0D62_09190) 1926442..1926912 - 471 WP_000181399.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M0D62_RS09205 (M0D62_09195) 1926914..1928044 - 1131 WP_047437333.1 tRNA epoxyqueuosine(34) reductase QueG -
M0D62_RS09210 (M0D62_09200) 1928195..1928917 - 723 WP_000590808.1 amino acid ABC transporter ATP-binding protein -
M0D62_RS09215 (M0D62_09205) 1928910..1930367 - 1458 WP_047437330.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 6019.42 Da        Isoelectric Point: 4.1469

>T242741 WP_000031103.1 NZ_CP096114:c1925651-1925496 [Staphylococcus argenteus]
MSKDKDAKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKSTDEKNSH

Download         Length: 156 bp

>T242741 NZ_OW967178:152559-152744 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22438.57 Da        Isoelectric Point: 5.3935

>AT242741 WP_047430475.1 NZ_CP096114:c1926283-1925684 [Staphylococcus argenteus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDNKKSYFEALGV
PASQIYPIAFEKDAIEFISDKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKKEVVEKLYQENGK
TSFEPSDLKSHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT242741 NZ_OW967178:152761-153171 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGTGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACTACGCTTTCCAGGATGCGCGAAGTGCACTGGTCGCGCACTTCGAAACCTTATGCGAGATGA
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCAAAAAGATTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTATGCCAACAGAAGTGCGTTTCTGGCGGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7PZK3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7JVF2

References