Detailed information of TA system TA242738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 840698..841175
• Replicon: chromosome
• Accession: NZ_CP096114
• Organism: Staphylococcus argenteus strain MRSA-139-14-168

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: A0A7U7JTG2
• Locus tag: M0D62_RS04000
• Protein ID: WP_000172413.1
• Coordinates: 840698..840886 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: A0A7U7JTE3
• Locus tag: M0D62_RS04005
• Protein ID: WP_000790107.1
• Coordinates: 840915..841175 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0D62_RS03970 (M0D62_03965)	836338..836820	+	483	WP_088811220.1	hypothetical protein	-
M0D62_RS03975 (M0D62_03970)	837163..837831	+	669	WP_047433960.1	thermonuclease family protein	-
M0D62_RS03980 (M0D62_03975)	838195..838395	+	201	WP_001059082.1	cold-shock protein	-
M0D62_RS03985 (M0D62_03980)	839008..839220	-	213	WP_001007088.1	hypothetical protein	-
M0D62_RS03990 (M0D62_03985)	839281..839565	-	285	WP_031788101.1	hypothetical protein	-
M0D62_RS03995 (M0D62_03990)	839654..840223	-	570	WP_047430023.1	lipoprotein N-acylation protein LnsA	-
M0D62_RS04000 (M0D62_03995)	840698..840886	-	189	WP_000172413.1	hypothetical protein	Toxin
M0D62_RS04005 (M0D62_04000)	840915..841175	-	261	WP_000790107.1	hypothetical protein	Antitoxin
M0D62_RS04010 (M0D62_04005)	841515..841718	+	204	WP_047433962.1	sterile alpha motif-like domain-containing protein	-
M0D62_RS04015 (M0D62_04010)	841715..841951	-	237	WP_000368686.1	hypothetical protein	-
M0D62_RS04020 (M0D62_04015)	842176..842757	+	582	WP_031788103.1	histidine phosphatase family protein	-
M0D62_RS04025 (M0D62_04020)	842824..843441	-	618	WP_248129764.1	LysE family transporter	-
M0D62_RS04030 (M0D62_04025)	843605..844096	-	492	WP_000695603.1	GNAT family N-acetyltransferase	-
M0D62_RS04035 (M0D62_04030)	844503..844925	-	423	WP_047433964.1	organic hydroperoxide resistance protein	-
M0D62_RS04040 (M0D62_04035)	845074..845793	+	720	WP_047433966.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7192.89 Da
• Isoelectric Point: 9.9971

>T242738 WP_000172413.1 NZ_CP096114:c840886-840698 [Staphylococcus argenteus]
MTLHFAILFWLALIFIVAGTFIFVLMKKTAKESKKESYLSFAVIFYIFGFAMLIYTLIFGIL

Nucleotide

• Length: 189 bp

>T242738 NZ_OW967004:c69100-68822 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10089.30 Da
• Isoelectric Point: 4.1927

>AT242738 WP_000790107.1 NZ_CP096114:c841175-840915 [Staphylococcus argenteus]
MKNIQLNAINLVITIIFAIFNIMITYNKDLDDLCWLLPGIIICGSILIVSFTIAMITKFWLSEILFFINIVLVLYYIYPI
FYDFIN

Nucleotide

• Length: 261 bp

>AT242738 NZ_OW967004:c69369-69100 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA

Structures

Toxin

• AlphaFold DB: A0A7U7JTG2

Antitoxin

• AlphaFold DB: A0A7U7JTE3