Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 4293569..4294143 Replicon chromosome
Accession NZ_CP096040
Organism Caulobacter segnis strain RL271

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MZV50_RS20015 Protein ID WP_252631031.1
Coordinates 4293569..4293904 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MZV50_RS20020 Protein ID WP_252631032.1
Coordinates 4293901..4294143 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZV50_RS19990 (MZV50_19985) 4289144..4289485 + 342 WP_252631027.1 GFA family protein -
MZV50_RS19995 (MZV50_19990) 4289492..4290862 - 1371 WP_252631028.1 hypothetical protein -
MZV50_RS20000 (MZV50_19995) 4291023..4292378 - 1356 WP_252635281.1 ATP-binding protein -
MZV50_RS20005 (MZV50_20000) 4292418..4293095 - 678 WP_252631029.1 response regulator transcription factor -
MZV50_RS20010 (MZV50_20005) 4293105..4293431 - 327 WP_252631030.1 PepSY domain-containing protein -
MZV50_RS20015 (MZV50_20010) 4293569..4293904 - 336 WP_252631031.1 endoribonuclease MazF Toxin
MZV50_RS20020 (MZV50_20015) 4293901..4294143 - 243 WP_252631032.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MZV50_RS20025 (MZV50_20020) 4294206..4296788 - 2583 WP_252631033.1 TonB-dependent receptor -
MZV50_RS20030 (MZV50_20025) 4296988..4297929 - 942 WP_252631034.1 DnaJ C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-108)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 11893.88 Da        Isoelectric Point: 9.9687

>T242730 WP_252631031.1 NZ_CP096040:c4293904-4293569 [Caulobacter segnis]
VSARYVPDAGDIVWLQFDPQAGHEQAGHRPALVLSPAAYNGKRGMMLCCPMTSRIKGYPFEVVVPGVSPSAVLADQIKSV
DWVARRAARKDVAPPGVLAETRAKLKALLSV

Download         Length: 336 bp

>T242730 NZ_OW967003:c2571369-2571019 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8949.12 Da        Isoelectric Point: 4.1839

>AT242730 WP_252631032.1 NZ_CP096040:c4294143-4293901 [Caulobacter segnis]
MHVVVKKWGNSASVRIPARVMAAADLSIDQAVDVREENGRIIIEPIREPEYDLDAMLAEMEPDTFHEDVDFGAPAGKEVW

Download         Length: 243 bp

>AT242730 NZ_OW967003:c2571614-2571363 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References